PDF(Pubmed)
Abstract：
UNASSIGNED: We aimed to use the onset time of Alzheimer\'s disease (AD) as the reference time to longitudinally investigate the atrophic characteristics of brain structures prior to the onset of AD.
UNASSIGNED: A total of 328 participants from the ADNI database with clear onset of AD and structural imaging data were included in our study. The time before the onset of AD (abbreviated as BAD) was calculated. We investigated the longitudinal brain changes in 97 regions using multivariate linear mixed effects regression models.
UNASSIGNED: The average BAD was -28.15 months, with a range from -156 to 0 months. The 54 brain regions showed significant atrophy prior to the onset of AD, and these regions were mainly distributed in the frontal and temporal lobes. The parietal and occipital lobe exhibited relatively less atrophy than the other brain lobes. Sex, age, and magnetic field strength had greater direct impacts on structural indicators than APOE genotype and education. The analysis of interaction effects revealed that the APOE ε4 mutation carriers exhibited more severe structural changes in specific brain regions as the BAD increased. However, sex, age, and education had minimal regulatory influence on the structural changes associated with BAD.
UNASSIGNED: Longitudinal analysis, with the onset time point of AD as the reference, can accurately describe the features of structural changes preceding the onset of AD and provide a comprehensive understanding of AD development.
UNASSIGNED: A total of 328 participants from the ADNI database with clear onset of AD and structural imaging data were included in our study. The time before the onset of AD (abbreviated as BAD) was calculated. We investigated the longitudinal brain changes in 97 regions using multivariate linear mixed effects regression models.
UNASSIGNED: The average BAD was -28.15 months, with a range from -156 to 0 months. The 54 brain regions showed significant atrophy prior to the onset of AD, and these regions were mainly distributed in the frontal and temporal lobes. The parietal and occipital lobe exhibited relatively less atrophy than the other brain lobes. Sex, age, and magnetic field strength had greater direct impacts on structural indicators than APOE genotype and education. The analysis of interaction effects revealed that the APOE ε4 mutation carriers exhibited more severe structural changes in specific brain regions as the BAD increased. However, sex, age, and education had minimal regulatory influence on the structural changes associated with BAD.
UNASSIGNED: Longitudinal analysis, with the onset time point of AD as the reference, can accurately describe the features of structural changes preceding the onset of AD and provide a comprehensive understanding of AD development.
摘要：
■我们旨在使用阿尔茨海默病（AD）的发病时间作为参考时间，以纵向研究AD发病前大脑结构的萎缩性特征。
■我们的研究纳入了ADNI数据库中的328名参与者，这些参与者具有明确的AD发病和结构影像学数据。计算AD发病前的时间(缩写为BAD)。我们使用多元线性混合效应回归模型研究了97个区域的纵向大脑变化。
■平均不良为-28.15个月，范围从-156到0个月。在AD发作之前，54个脑区显示出明显的萎缩，这些区域主要分布在额叶和颞叶。顶叶和枕叶比其他脑叶萎缩相对较少。性,年龄,与APOE基因型和教育程度相比，磁场强度对结构指标的直接影响更大。相互作用效应的分析表明，随着BAD的增加，APOEε4突变携带者在特定的大脑区域表现出更严重的结构变化。然而,性别,年龄,教育对与BAD相关的结构变化的监管影响最小。
■纵向分析，以AD的发病时间点为参考，可以准确描述AD发病前的结构变化特征，并提供对AD发展的全面了解。
■我们的研究纳入了ADNI数据库中的328名参与者，这些参与者具有明确的AD发病和结构影像学数据。计算AD发病前的时间(缩写为BAD)。我们使用多元线性混合效应回归模型研究了97个区域的纵向大脑变化。
■平均不良为-28.15个月，范围从-156到0个月。在AD发作之前，54个脑区显示出明显的萎缩，这些区域主要分布在额叶和颞叶。顶叶和枕叶比其他脑叶萎缩相对较少。性,年龄,与APOE基因型和教育程度相比，磁场强度对结构指标的直接影响更大。相互作用效应的分析表明，随着BAD的增加，APOEε4突变携带者在特定的大脑区域表现出更严重的结构变化。然而,性别,年龄,教育对与BAD相关的结构变化的监管影响最小。
■纵向分析，以AD的发病时间点为参考，可以准确描述AD发病前的结构变化特征，并提供对AD发展的全面了解。
