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Abstract：
UNASSIGNED: The effect of immune cells on autoimmune diseases (ADs) complicated by non-Hodgkin lymphoma (NHL) has been widely recognized, but a causal relationship between regulatory T cell (Treg) immune traits and ADs complicated by NHL remains debated.
UNASSIGNED: Aggregate data for 84 Treg-related immune traits were downloaded from the Genome-Wide Association Study (GWAS) catalog, and GWAS data for diffuse large B-cell lymphoma (DLBCL; n=315243), follicular lymphoma (FL; n=325831), sjögren\'s syndrome (SS; n=402090), rheumatoid arthritis (RA; n=276465), dermatopolymyositis (DM; n=311640), psoriasis (n=407876), atopic dermatitis (AD; n=382254), ulcerative colitis (UC; n=411317), crohn\'s disease(CD; n=411973) and systemic lupus erythematosus (SLE; n=307587) were downloaded from the FinnGen database. The inverse variance weighting (IVW) method was mainly used to infer any causal association between Treg-related immune traits and DLBCL, FL, SS, DM, RA, Psoriasis, AD, UC, CD and SLE, supplemented by MR-Egger, weighted median, simple mode, and weighted mode. Moreover, we performed sensitivity analyses to assess the validity of the causal relationships.
UNASSIGNED: There was a potential genetic predisposition association identified between CD39+ CD8br AC, CD39+ CD8br % T cell, and the risk of DLBCL (OR=1.51, p<0.001; OR=1.25, p=0.001) (adjusted FDR<0.1). Genetic prediction revealed potential associations between CD25++ CD8br AC, CD28- CD25++ CD8br % T cell, CD39+ CD8br % CD8br, and the risk of FL (OR=1.13, p=0.022; OR=1.28, p=0.042; OR=0.90, p=0.016) (adjusted FDR>0.1). Furthermore, SLE and CD exhibited a genetically predicted potential association with the CD39+ CD8+ Tregs subset. SS and DM were possibly associated with an increase in the quantity of the CD4+ Tregs subset; RA may have reduced the quantity of the CD39+ CD8+ Tregs subset, although no causal relationship was identified. Sensitivity analyses supported the robustness of our findings.
UNASSIGNED: There existed a genetically predicted potential association between the CD39+ CD8+ Tregs subset and the risk of DLBCL, while SLE and CD were genetically predicted to be potentially associated with the CD39+ CD8+ Tregs subset. The CD39+ CD8+ Tregs subset potentially aided in the clinical diagnosis and treatment of SLE or CD complicated by DLBCL.
UNASSIGNED: Aggregate data for 84 Treg-related immune traits were downloaded from the Genome-Wide Association Study (GWAS) catalog, and GWAS data for diffuse large B-cell lymphoma (DLBCL; n=315243), follicular lymphoma (FL; n=325831), sjögren\'s syndrome (SS; n=402090), rheumatoid arthritis (RA; n=276465), dermatopolymyositis (DM; n=311640), psoriasis (n=407876), atopic dermatitis (AD; n=382254), ulcerative colitis (UC; n=411317), crohn\'s disease(CD; n=411973) and systemic lupus erythematosus (SLE; n=307587) were downloaded from the FinnGen database. The inverse variance weighting (IVW) method was mainly used to infer any causal association between Treg-related immune traits and DLBCL, FL, SS, DM, RA, Psoriasis, AD, UC, CD and SLE, supplemented by MR-Egger, weighted median, simple mode, and weighted mode. Moreover, we performed sensitivity analyses to assess the validity of the causal relationships.
UNASSIGNED: There was a potential genetic predisposition association identified between CD39+ CD8br AC, CD39+ CD8br % T cell, and the risk of DLBCL (OR=1.51, p<0.001; OR=1.25, p=0.001) (adjusted FDR<0.1). Genetic prediction revealed potential associations between CD25++ CD8br AC, CD28- CD25++ CD8br % T cell, CD39+ CD8br % CD8br, and the risk of FL (OR=1.13, p=0.022; OR=1.28, p=0.042; OR=0.90, p=0.016) (adjusted FDR>0.1). Furthermore, SLE and CD exhibited a genetically predicted potential association with the CD39+ CD8+ Tregs subset. SS and DM were possibly associated with an increase in the quantity of the CD4+ Tregs subset; RA may have reduced the quantity of the CD39+ CD8+ Tregs subset, although no causal relationship was identified. Sensitivity analyses supported the robustness of our findings.
UNASSIGNED: There existed a genetically predicted potential association between the CD39+ CD8+ Tregs subset and the risk of DLBCL, while SLE and CD were genetically predicted to be potentially associated with the CD39+ CD8+ Tregs subset. The CD39+ CD8+ Tregs subset potentially aided in the clinical diagnosis and treatment of SLE or CD complicated by DLBCL.
摘要：
■免疫细胞对自身免疫性疾病（AD）并发非霍奇金淋巴瘤（NHL）的影响已得到广泛认可，但是调节性T细胞（Treg）免疫特性与由NHL引起的AD之间的因果关系仍存在争议。
■84个与Treg相关的免疫性状的汇总数据是从全基因组关联研究（GWAS）目录下载的，和弥漫性大B细胞淋巴瘤的GWAS数据（DLBCL；n=315243），滤泡性淋巴瘤（FL；n=325831），干燥综合征（SS；n=402090），类风湿性关节炎（RA；n=276465），皮肌炎（DM；n=311640），牛皮癣（n=407876），特应性皮炎（AD；n=382254），溃疡性结肠炎（UC；n=411317），从FinnGen数据库下载克罗恩病(CD;n=411973)和系统性红斑狼疮(SLE;n=307587)。方差逆加权(IVW)方法主要用于推断Treg相关免疫性状与DLBCL之间的因果关系,FL,SS,DM,RA,牛皮癣,AD,UC,CD和SLE,由MR-Egger补充，加权中位数，简单模式，和加权模式。此外，我们进行了敏感性分析以评估因果关系的有效性.
■CD39+CD8brAC之间存在潜在的遗传易感性关联，CD39+CD8br%T细胞,和DLBCL的风险（OR=1.51，p<0.001；OR=1.25，p=0.001）（校正后的FDR<0.1）。遗传预测揭示了CD25++CD8brAC，CD28-CD25++CD8br%T细胞,CD39+CD8br%CD8br,和FL风险（OR=1.13，p=0.022；OR=1.28，p=0.042；OR=0.90，p=0.016）（调整后的FDR>0.1）。此外，SLE和CD表现出与CD39+CD8+Tregs亚群的遗传预测潜在关联。SS和DM可能与CD4+Tregs亚群的数量增加有关；RA可能减少了CD39+CD8+Tregs亚群的数量，尽管没有确定因果关系。敏感性分析支持我们研究结果的稳健性。
■CD39+CD8+Tregs亚群与DLBCL风险之间存在遗传预测的潜在关联，而遗传预测SLE和CD可能与CD39+CD8+Tregs亚群相关。CD39+CD8+Tregs亚群可能有助于SLE或CD并发DLBCL的临床诊断和治疗。
■84个与Treg相关的免疫性状的汇总数据是从全基因组关联研究（GWAS）目录下载的，和弥漫性大B细胞淋巴瘤的GWAS数据（DLBCL；n=315243），滤泡性淋巴瘤（FL；n=325831），干燥综合征（SS；n=402090），类风湿性关节炎（RA；n=276465），皮肌炎（DM；n=311640），牛皮癣（n=407876），特应性皮炎（AD；n=382254），溃疡性结肠炎（UC；n=411317），从FinnGen数据库下载克罗恩病(CD;n=411973)和系统性红斑狼疮(SLE;n=307587)。方差逆加权(IVW)方法主要用于推断Treg相关免疫性状与DLBCL之间的因果关系,FL,SS,DM,RA,牛皮癣,AD,UC,CD和SLE,由MR-Egger补充，加权中位数，简单模式，和加权模式。此外，我们进行了敏感性分析以评估因果关系的有效性.
■CD39+CD8brAC之间存在潜在的遗传易感性关联，CD39+CD8br%T细胞,和DLBCL的风险（OR=1.51，p<0.001；OR=1.25，p=0.001）（校正后的FDR<0.1）。遗传预测揭示了CD25++CD8brAC，CD28-CD25++CD8br%T细胞,CD39+CD8br%CD8br,和FL风险（OR=1.13，p=0.022；OR=1.28，p=0.042；OR=0.90，p=0.016）（调整后的FDR>0.1）。此外，SLE和CD表现出与CD39+CD8+Tregs亚群的遗传预测潜在关联。SS和DM可能与CD4+Tregs亚群的数量增加有关；RA可能减少了CD39+CD8+Tregs亚群的数量，尽管没有确定因果关系。敏感性分析支持我们研究结果的稳健性。
■CD39+CD8+Tregs亚群与DLBCL风险之间存在遗传预测的潜在关联，而遗传预测SLE和CD可能与CD39+CD8+Tregs亚群相关。CD39+CD8+Tregs亚群可能有助于SLE或CD并发DLBCL的临床诊断和治疗。
