PDF(Pubmed)
Abstract：
UNASSIGNED: The introduction of Highly Active Anti-Retroviral Therapy (HAART) has led to a dramatic decrease in Human Immune Deficiency Virus (HIV) related morbidity and mortality in the developed as well as developing world. Whilst HAART has been effective in reducing rapidly progressive retinopathies, there are other ocular manifestations of HIV which are yet to be determined, characterised and addressed. The aim of the study was to determine the effect of HAART on Accommodative-Convergence mechanism among HIV/AIDS patients in Northwestern, Nigeria.
UNASSIGNED: This was hospital-based cohort study carried out from April 2019 to November 2019. Participants that met the inclusion criteria were recruited and were separated into two groups A and B. Group A were those about to commence HAART referred to as HAART naive, while group B were subdivided into four groups; comprising of B1: those that had been on HAART for 0 - 2½ years, group B2: >2½ - 5 years, group B3: >5 - 7½ years, and group B4: >7½ - 10 years, termed as HAART experience. Information obtained from the patients included sex, age, marital status, Near Point of Convergence (NPC), Amplitude of Accommodation (AA), Presbyopic reading Addition (ADD), CD4+ T cell count, HAART regimen and duration on HAART therapy.
UNASSIGNED: There were 400 participants aged 25 - 55years with a mean age of 37.86 ± 7.5years. The participant\'s NPC mean was 6.4 ± 1.47cm with a range of 2 - 18cm. Most of the participants 336 (84.0%) had an abnormal Near Point of Convergence compared to 64 (16%) with normal NPC values. The mean AA was 4.18± 1.34DS, ranging from 0.75 to 10.0DS and about 273 (68.2%) of the participant\'s AA was within 3 to 5DS. The mean presbyopic addition was 1.39± 0.98 DS ranging from 1.00 to 3.50DS whilst majority of the participants, 305 (76.2%) had an abnormal Reading Addition.
UNASSIGNED: The study showed that the HIV/AIDS patients on HAART exhibit an abnormally low AA, receded NPC and High presbyopic reading addition as compared to age matched HAART naïve. There was a statistically significant association between AA and HAART (p = 0.002) and HAART duration (p = 0.00), but there was no association with their CD4+ T cell levels and HAART regimen (p = 0.12, p = 0.08). There was no statistically significant association between Abnormal reading addition and HAART (p= 0.46), CD4+4 T cell levels and HAART regimen (p=0.53 and p= 0.59), but there was a statistically significant association with HAART duration (p= 0.00).
UNASSIGNED: This was hospital-based cohort study carried out from April 2019 to November 2019. Participants that met the inclusion criteria were recruited and were separated into two groups A and B. Group A were those about to commence HAART referred to as HAART naive, while group B were subdivided into four groups; comprising of B1: those that had been on HAART for 0 - 2½ years, group B2: >2½ - 5 years, group B3: >5 - 7½ years, and group B4: >7½ - 10 years, termed as HAART experience. Information obtained from the patients included sex, age, marital status, Near Point of Convergence (NPC), Amplitude of Accommodation (AA), Presbyopic reading Addition (ADD), CD4+ T cell count, HAART regimen and duration on HAART therapy.
UNASSIGNED: There were 400 participants aged 25 - 55years with a mean age of 37.86 ± 7.5years. The participant\'s NPC mean was 6.4 ± 1.47cm with a range of 2 - 18cm. Most of the participants 336 (84.0%) had an abnormal Near Point of Convergence compared to 64 (16%) with normal NPC values. The mean AA was 4.18± 1.34DS, ranging from 0.75 to 10.0DS and about 273 (68.2%) of the participant\'s AA was within 3 to 5DS. The mean presbyopic addition was 1.39± 0.98 DS ranging from 1.00 to 3.50DS whilst majority of the participants, 305 (76.2%) had an abnormal Reading Addition.
UNASSIGNED: The study showed that the HIV/AIDS patients on HAART exhibit an abnormally low AA, receded NPC and High presbyopic reading addition as compared to age matched HAART naïve. There was a statistically significant association between AA and HAART (p = 0.002) and HAART duration (p = 0.00), but there was no association with their CD4+ T cell levels and HAART regimen (p = 0.12, p = 0.08). There was no statistically significant association between Abnormal reading addition and HAART (p= 0.46), CD4+4 T cell levels and HAART regimen (p=0.53 and p= 0.59), but there was a statistically significant association with HAART duration (p= 0.00).
摘要：
高活性抗逆转录病毒疗法(HAART)的引入导致发达国家和发展中国家中与人类免疫缺陷病毒(HIV)相关的发病率和死亡率的显著降低。虽然HAART已有效减少快速进行性视网膜病变，艾滋病毒的其他眼部表现尚待确定，表征和解决。该研究的目的是确定HAART对西北地区HIV/AIDS患者的调节-融合机制的影响。尼日利亚。
■这是基于医院的队列研究，于2019年4月至2019年11月进行。招募符合纳入标准的参与者，将其分为A组和B两组。而B组被细分为四组；由B1组成：那些已经接受HAART治疗0-2½年的患者，B2组：>2½-5年，B3组：>5-7½年，和B4组：>7½-10年，称为HAART体验。从患者那里获得的信息包括性别，年龄,婚姻状况,近收敛点（NPC），住宿幅度（AA），老花眼阅读添加（ADD），CD4+T细胞计数,HAART方案和HAART治疗的持续时间。
■有400名参与者，年龄在25-55岁之间，平均年龄为37.86±7.5岁。参与者的NPC平均值为6.4±1.47cm，范围为2-18cm。与具有正常NPC值的64(16%)相比,大多数参与者336(84.0%)具有异常近点收敛。平均AA为4.18±1.34DS，范围为0.75至10.0DS，约273名(68.2%)参与者的AA在3至5DS之间。平均老花眼添加量为1.39±0.98DS，范围为1.00至3.50DS，而大多数参与者，305（76.2%）的阅读增加异常。
■研究表明，接受HAART的HIV/AIDS患者表现出异常低的AA，与年龄匹配的HAART天真相比，NPC和老花眼读数增加减少。AA和HAART（p=0.002）与HAART持续时间（p=0.00）之间存在统计学上的显着关联，但与他们的CD4+T细胞水平和HAART方案无关(p=0.12,p=0.08).异常阅读添加与HAART之间没有统计学上的显着关联（p=0.46），CD4+4T细胞水平和HAART方案（p=0.53和p=0.59），但与HAART持续时间有统计学显著关联(p=0.00).
■这是基于医院的队列研究，于2019年4月至2019年11月进行。招募符合纳入标准的参与者，将其分为A组和B两组。而B组被细分为四组；由B1组成：那些已经接受HAART治疗0-2½年的患者，B2组：>2½-5年，B3组：>5-7½年，和B4组：>7½-10年，称为HAART体验。从患者那里获得的信息包括性别，年龄,婚姻状况,近收敛点（NPC），住宿幅度（AA），老花眼阅读添加（ADD），CD4+T细胞计数,HAART方案和HAART治疗的持续时间。
■有400名参与者，年龄在25-55岁之间，平均年龄为37.86±7.5岁。参与者的NPC平均值为6.4±1.47cm，范围为2-18cm。与具有正常NPC值的64(16%)相比,大多数参与者336(84.0%)具有异常近点收敛。平均AA为4.18±1.34DS，范围为0.75至10.0DS，约273名(68.2%)参与者的AA在3至5DS之间。平均老花眼添加量为1.39±0.98DS，范围为1.00至3.50DS，而大多数参与者，305（76.2%）的阅读增加异常。
■研究表明，接受HAART的HIV/AIDS患者表现出异常低的AA，与年龄匹配的HAART天真相比，NPC和老花眼读数增加减少。AA和HAART（p=0.002）与HAART持续时间（p=0.00）之间存在统计学上的显着关联，但与他们的CD4+T细胞水平和HAART方案无关(p=0.12,p=0.08).异常阅读添加与HAART之间没有统计学上的显着关联（p=0.46），CD4+4T细胞水平和HAART方案（p=0.53和p=0.59），但与HAART持续时间有统计学显著关联(p=0.00).
