Abstract：
UNASSIGNED: Menopause is a physiological period characterized by the cessation of ovarian activity. Sequential changes during this transition affect multiple systems, including the brain. Sixty percent of women experience cognitive impairment. The objective of this review is to show the neuroprotective effect of hormone replacement therapy (HRT) through the different scales and whether there is a benefit of this in women.
UNASSIGNED: A search was conducted in six databases. Eligibility criteria included women within 10 years of menopause, receiving HRT controlled with placebo, studies lasting more than 6 months and women without a history of chronic underlying pathology.
UNASSIGNED: A total of nine randomized controlled trials met the inclusion criteria. Regarding memory, two studies reported better performance of HRT with a significant odds ratio (OR) of 0.67; regarding attention, one study reported potential improvement in women receiving HRT with a significant OR of 0.87; and neuroimaging assessment found an increase in ventricular volume compared to placebo over a 3-year period.
UNASSIGNED: The early initiation of menopausal HRT in healthy women appears to yield a positive effect on certain cognitive aspects, such as attention and cortical volume in the central nervous system. These findings should be confirmed through future prospective studies.
UNASSIGNED: A search was conducted in six databases. Eligibility criteria included women within 10 years of menopause, receiving HRT controlled with placebo, studies lasting more than 6 months and women without a history of chronic underlying pathology.
UNASSIGNED: A total of nine randomized controlled trials met the inclusion criteria. Regarding memory, two studies reported better performance of HRT with a significant odds ratio (OR) of 0.67; regarding attention, one study reported potential improvement in women receiving HRT with a significant OR of 0.87; and neuroimaging assessment found an increase in ventricular volume compared to placebo over a 3-year period.
UNASSIGNED: The early initiation of menopausal HRT in healthy women appears to yield a positive effect on certain cognitive aspects, such as attention and cortical volume in the central nervous system. These findings should be confirmed through future prospective studies.
摘要：
■更年期是以卵巢活动停止为特征的生理时期。此转换过程中的顺序更改会影响多个系统，包括大脑。60%的女性经历认知障碍。这篇综述的目的是通过不同的尺度显示激素替代疗法（HRT）的神经保护作用，以及是否对女性有益。
■在六个数据库中进行了搜索。资格标准包括更年期10年内的女性，接受安慰剂控制的HRT，研究持续超过6个月，女性没有慢性基础病理史。
■共有9项随机对照试验符合纳入标准。关于记忆，两项研究报告HRT表现更好，显著优势比(OR)为0.67；关于注意力，一项研究报告,接受HRT的女性有潜在改善,显著OR为0.87;神经影像学评估发现,与安慰剂相比,3年后心室容积增加.
■健康女性早期开始更年期HRT似乎对某些认知方面产生积极影响，例如中枢神经系统的注意力和皮质体积。这些发现应该通过未来的前瞻性研究得到证实。
■在六个数据库中进行了搜索。资格标准包括更年期10年内的女性，接受安慰剂控制的HRT，研究持续超过6个月，女性没有慢性基础病理史。
■共有9项随机对照试验符合纳入标准。关于记忆，两项研究报告HRT表现更好，显著优势比(OR)为0.67；关于注意力，一项研究报告,接受HRT的女性有潜在改善,显著OR为0.87;神经影像学评估发现,与安慰剂相比,3年后心室容积增加.
■健康女性早期开始更年期HRT似乎对某些认知方面产生积极影响，例如中枢神经系统的注意力和皮质体积。这些发现应该通过未来的前瞻性研究得到证实。
