PDF(Pubmed)
Abstract：
OBJECTIVE: To investigate the efficacy and safety of pulsed radiofrequency of the dorsal root ganglion combined with ozone injection for treating acute herpes zoster (HZ) neuralgia in middle-aged and elderly adults.
METHODS: A total of 164 middle-aged and elderly patients with acute HZ were randomly assigned to 2 groups: the pulsed radiofrequency combined with ozone injection group (group A) and the pulsed radiofrequency group (group B). The therapeutic effects were evaluated using Numeric Rating Scale (NRS) scores and the average doses of gabapentin (mg/d) preoperatively and 1 day, 2 weeks, 4 weeks, 12 weeks, and 24 weeks postoperatively. The incidence of clinically significant postherpetic neuralgia (PHN) and complications in the 2 groups were recorded.
RESULTS: The data showed that the NRS scores and the doses of gabapentin after treatment were significantly lower when compared with the baseline values in both groups. Compared with group B, the NRS scores and the doses of postoperative gabapentin were significantly lower in group A. The incidence of PHN was significantly lower at weeks 4, 12, and 24 in group A than in group B. No adverse reactions occurred in either of the 2 groups post-treatment.
CONCLUSIONS: The results indicated that ozone injection in the dorsal root ganglion combined with pulsed radiofrequency therapy was more effective in treating acute HZ neuralgia in middle-aged and elderly adults. It provides patients with longer-lasting pain relief, decreased incidence of PHN and the doses of medication, and improved quality of life than with Pulsed Radiofrequency treatment.
METHODS: A total of 164 middle-aged and elderly patients with acute HZ were randomly assigned to 2 groups: the pulsed radiofrequency combined with ozone injection group (group A) and the pulsed radiofrequency group (group B). The therapeutic effects were evaluated using Numeric Rating Scale (NRS) scores and the average doses of gabapentin (mg/d) preoperatively and 1 day, 2 weeks, 4 weeks, 12 weeks, and 24 weeks postoperatively. The incidence of clinically significant postherpetic neuralgia (PHN) and complications in the 2 groups were recorded.
RESULTS: The data showed that the NRS scores and the doses of gabapentin after treatment were significantly lower when compared with the baseline values in both groups. Compared with group B, the NRS scores and the doses of postoperative gabapentin were significantly lower in group A. The incidence of PHN was significantly lower at weeks 4, 12, and 24 in group A than in group B. No adverse reactions occurred in either of the 2 groups post-treatment.
CONCLUSIONS: The results indicated that ozone injection in the dorsal root ganglion combined with pulsed radiofrequency therapy was more effective in treating acute HZ neuralgia in middle-aged and elderly adults. It provides patients with longer-lasting pain relief, decreased incidence of PHN and the doses of medication, and improved quality of life than with Pulsed Radiofrequency treatment.
摘要：
目的：观察背根神经节脉冲射频联合臭氧注射治疗中老年急性带状疱疹神经痛的疗效和安全性。
方法：将164例中老年急性带状疱疹患者随机分为2组：脉冲射频联合臭氧注射组（A组）和脉冲射频组（B组）。使用数字评定量表（NRS）评分和加巴喷丁的平均剂量（mg/天）评估术前和1天的治疗效果，2周,4周,12周,术后24周。记录两组有临床意义的带状疱疹后遗神经痛（PHN）的发生率和并发症。
结果：数据显示，与基线值相比，两组治疗后的NRS评分和加巴喷丁剂量均显着降低。与B组相比,A组术后NRS评分和加巴喷丁剂量明显低于B组,4、12、24周PHN发生率明显低于B组。
结论：背根神经节臭氧注射联合脉冲射频治疗对中老年人急性带状疱疹神经痛的治疗效果更好。它为患者提供更持久的疼痛缓解，减少PHN的发生率和药物剂量，与PRF治疗相比，生活质量有所提高。
方法：将164例中老年急性带状疱疹患者随机分为2组：脉冲射频联合臭氧注射组（A组）和脉冲射频组（B组）。使用数字评定量表（NRS）评分和加巴喷丁的平均剂量（mg/天）评估术前和1天的治疗效果，2周,4周,12周,术后24周。记录两组有临床意义的带状疱疹后遗神经痛（PHN）的发生率和并发症。
结果：数据显示，与基线值相比，两组治疗后的NRS评分和加巴喷丁剂量均显着降低。与B组相比,A组术后NRS评分和加巴喷丁剂量明显低于B组,4、12、24周PHN发生率明显低于B组。
结论：背根神经节臭氧注射联合脉冲射频治疗对中老年人急性带状疱疹神经痛的治疗效果更好。它为患者提供更持久的疼痛缓解，减少PHN的发生率和药物剂量，与PRF治疗相比，生活质量有所提高。
