Abstract：
In order to improve the biological effect of proton therapy, the authors first propose a new method of boron-based proton-enhanced radiotherapy in a \" ternary \" radiotherapy mode, based on the existing sensitizing effect of proton radiotherapy: i.e, Boron-based mediators (11B and 10B) induce the proton-hydrogen-boron fusion reaction of the low-energy protons arriving at the Bragg peak region of the tumor target area (p+11B→3α) and thermal neutron capture (10B+n→7Li3+(0.84 MeV)+4He2+(1.47 MeV)+γ(0.477 MeV)), which release low-energy α-particles with high LETs to enhance the biological effect of proton dose in the target area, thus improve the clinical effect of proton therapy. Then, the advantages and disadvantages of the \"ternary\" model were analyzed from the theoretical basis and current research status, and finally, the \"ternary\" model is summarized and prospected.
为了提高质子治疗的生物学效应，首先在现有质子放射治疗增敏效应的基础上，提出了硼基质子增强放疗的“三元”放疗模式的新方法：即以硼基介质（11B和10B）诱导抵达肿瘤靶区的布拉格峰区低能质子发生质子氢硼聚变反应(p+11B→3α)和热中子俘获(10B+n→7Li3+(0.84 MeV)+4He2+(1.47 MeV)+γ(0.477 MeV))两种核反应，释出高LET的低能α粒子以增强靶区质子剂量的生物效应，从而提高质子治疗的临床效应。然后根据“三元”模型理论基础和研究现状分析了模型的优缺点，最后对“三元”模型进行了总结与展望。.
为了提高质子治疗的生物学效应，首先在现有质子放射治疗增敏效应的基础上，提出了硼基质子增强放疗的“三元”放疗模式的新方法：即以硼基介质（11B和10B）诱导抵达肿瘤靶区的布拉格峰区低能质子发生质子氢硼聚变反应(p+11B→3α)和热中子俘获(10B+n→7Li3+(0.84 MeV)+4He2+(1.47 MeV)+γ(0.477 MeV))两种核反应，释出高LET的低能α粒子以增强靶区质子剂量的生物效应，从而提高质子治疗的临床效应。然后根据“三元”模型理论基础和研究现状分析了模型的优缺点，最后对“三元”模型进行了总结与展望。.
摘要：
暂无翻译
