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Abstract：
OBJECTIVE: Glaucoma is a chronic disease with an insidious onset that often brings severe psychological burden to patients. Therefore, based on a systematic review and meta-analysis, we explore the prevalence and severity of depression and anxiety in glaucoma patients, and provide clinically valuable information for medical staff.
METHODS: Computer searches were conducted for relevant studies in PubMed, Embase, ProQuest PsycINFO, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Web of Science, The Cochrane Library, Chinese Biomedical Literature Database (CBM), China National Knowledge Infrastructure, Wanfang Database, and China VIP Database. The search date range was from the establishment of the database to December 2023. Literature was screened and data were extracted. The Cochrane risk of bias assessment tool was used to evaluate the quality of the literature, and RevMan5.4 was used for meta-analysis.
RESULTS: The total sample size of the 15 included studies was 24,334 cases. All included studies were of high quality. The results of the meta-analysis revealed that, compared with control patients without glaucoma, patients with glaucoma were more likely to experience depression and to have more severe depressive symptoms [RR (Relative Risk) = 5.92, 95% CI (Confidence Interva) (3.29, 10.66), p < 0.01]; they were also more likely to experience anxiety and to have more severe anxiety symptoms [RR = 2.99, 95% CI (1.93, 4.64), p < 0.01]. The results of the sensitivity analysis showed that the two studies by Cumurcu E. 2005 and Yochim 2012 were the sources of heterogeneity in the meta-analysis of depression; and the three studies by Mabuchi 2012, Otori 2017, and Yochim 2012 were the sources of heterogeneity in the meta-analysis of anxiety disorders.
CONCLUSIONS: People with glaucoma are more likely to experience depression and anxiety than people without glaucoma. Medical staff should pay greater attention to patients\' emotional problems and help patients improve their quality of life.
METHODS: Computer searches were conducted for relevant studies in PubMed, Embase, ProQuest PsycINFO, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Web of Science, The Cochrane Library, Chinese Biomedical Literature Database (CBM), China National Knowledge Infrastructure, Wanfang Database, and China VIP Database. The search date range was from the establishment of the database to December 2023. Literature was screened and data were extracted. The Cochrane risk of bias assessment tool was used to evaluate the quality of the literature, and RevMan5.4 was used for meta-analysis.
RESULTS: The total sample size of the 15 included studies was 24,334 cases. All included studies were of high quality. The results of the meta-analysis revealed that, compared with control patients without glaucoma, patients with glaucoma were more likely to experience depression and to have more severe depressive symptoms [RR (Relative Risk) = 5.92, 95% CI (Confidence Interva) (3.29, 10.66), p < 0.01]; they were also more likely to experience anxiety and to have more severe anxiety symptoms [RR = 2.99, 95% CI (1.93, 4.64), p < 0.01]. The results of the sensitivity analysis showed that the two studies by Cumurcu E. 2005 and Yochim 2012 were the sources of heterogeneity in the meta-analysis of depression; and the three studies by Mabuchi 2012, Otori 2017, and Yochim 2012 were the sources of heterogeneity in the meta-analysis of anxiety disorders.
CONCLUSIONS: People with glaucoma are more likely to experience depression and anxiety than people without glaucoma. Medical staff should pay greater attention to patients\' emotional problems and help patients improve their quality of life.
摘要：
目的：青光眼是一种发病隐匿的慢性疾病，常给患者带来严重的心理负担。因此,基于系统的回顾和荟萃分析，我们探讨青光眼患者抑郁和焦虑的患病率和严重程度，为医务人员提供有临床价值的信息。
方法：在PubMed，Embase,ProQuestPsycINFO,护理和相关健康文献累积指数(CINAHL)，WebofScience,科克伦图书馆,中国生物医学文献数据库(CBM),中国国家知识基础设施，万方数据库,和中国VIP数据库。搜索日期范围是从数据库建立到2023年12月。筛选文献并提取数据。使用Cochrane偏差风险评估工具来评估文献质量，使用RevMan5.4进行荟萃分析。
结果：15项纳入研究的总样本量为24,334例。所有纳入的研究都是高质量的。荟萃分析的结果表明，与没有青光眼的对照组患者相比，青光眼患者更有可能出现抑郁和更严重的抑郁症状[RR(相对风险)=5.92,95%CI(置信区间)(3.29,10.66),p<0.01];他们也更有可能经历焦虑和有更严重的焦虑症状[RR=2.99,95%CI(1.93,4.64),p<0.01]。敏感性分析结果显示,CumurcuE.2005和Yochim2012的两项研究是抑郁症meta分析的异质性来源;Mabuchi2012、Otori2017和Yochim2012的三项研究是焦虑症meta分析的异质性来源。
结论：患有青光眼的人比没有青光眼的人更容易经历抑郁和焦虑。医务人员应更加关注患者的情绪问题，帮助患者提高生活质量。
方法：在PubMed，Embase,ProQuestPsycINFO,护理和相关健康文献累积指数(CINAHL)，WebofScience,科克伦图书馆,中国生物医学文献数据库(CBM),中国国家知识基础设施，万方数据库,和中国VIP数据库。搜索日期范围是从数据库建立到2023年12月。筛选文献并提取数据。使用Cochrane偏差风险评估工具来评估文献质量，使用RevMan5.4进行荟萃分析。
结果：15项纳入研究的总样本量为24,334例。所有纳入的研究都是高质量的。荟萃分析的结果表明，与没有青光眼的对照组患者相比，青光眼患者更有可能出现抑郁和更严重的抑郁症状[RR(相对风险)=5.92,95%CI(置信区间)(3.29,10.66),p<0.01];他们也更有可能经历焦虑和有更严重的焦虑症状[RR=2.99,95%CI(1.93,4.64),p<0.01]。敏感性分析结果显示,CumurcuE.2005和Yochim2012的两项研究是抑郁症meta分析的异质性来源;Mabuchi2012、Otori2017和Yochim2012的三项研究是焦虑症meta分析的异质性来源。
结论：患有青光眼的人比没有青光眼的人更容易经历抑郁和焦虑。医务人员应更加关注患者的情绪问题，帮助患者提高生活质量。
