PDF(Pubmed)
Abstract：
BACKGROUND: The neurobiological basis of delusional disorder is less explored through neuroimaging techniques than in other psychotic disorders. This study aims to provide information about the neural origins of delusional disorder (DD) by examining the neuroanatomical features of some basal nuclei with magnetic resonance imaging (MRI) texture analysis.
METHODS: Twenty DD patients and 20 healthy individuals were included in the study. Globus pallidus, putamen, and caudate nuclei were selected individually with a region of interest (ROI) on the axial MRI images. The entire texture analysis algorithm applied to all selected ROIs was done with an in-house software. Nuclei on both sides were taken as separate samples.
RESULTS: There were no significant differences between groups in terms of age and gender. The average \"mean, median and maximum\" values of all three nuclei were decreased in DD patients. The small putamen area and the differences detected in different tissue parameters for all three nuclei in delusional disorder patients indicate that they differ in delusional disorder from normal controls (p < 0.05).
CONCLUSIONS: The differences detected in the texture parameters for all three nuclei indicate that there is something different in the DD from in the normal controls. Neuroimaging studies with larger samples and different techniques in the future may shed light on the etiology of delusional disorder.
METHODS: Twenty DD patients and 20 healthy individuals were included in the study. Globus pallidus, putamen, and caudate nuclei were selected individually with a region of interest (ROI) on the axial MRI images. The entire texture analysis algorithm applied to all selected ROIs was done with an in-house software. Nuclei on both sides were taken as separate samples.
RESULTS: There were no significant differences between groups in terms of age and gender. The average \"mean, median and maximum\" values of all three nuclei were decreased in DD patients. The small putamen area and the differences detected in different tissue parameters for all three nuclei in delusional disorder patients indicate that they differ in delusional disorder from normal controls (p < 0.05).
CONCLUSIONS: The differences detected in the texture parameters for all three nuclei indicate that there is something different in the DD from in the normal controls. Neuroimaging studies with larger samples and different techniques in the future may shed light on the etiology of delusional disorder.
摘要：
背景：与其他精神病性精神障碍相比，通过神经影像学技术探索妄想障碍的神经生物学基础较少。本研究旨在通过磁共振成像（MRI）纹理分析检查某些基底核的神经解剖特征，提供有关妄想症（DD）的神经起源的信息。
方法：20名DD患者和20名健康人纳入研究。苍白无力，壳核,在轴向MRI图像上单独选择尾状核和感兴趣区域（ROI）。应用于所有选择的ROI的整个纹理分析算法是用内部软件完成的。取两侧的核作为单独的样品。
结果：两组之间在年龄和性别方面没有显着差异。平均“意味着，DD患者3个细胞核的中值和最大值均降低.妄想症患者中所有三个核的小壳核面积和在不同组织参数中检测到的差异表明它们在妄想症方面与正常对照不同(p<0.05)。
结论：在所有三个核的质地参数中检测到的差异表明，DD与正常对照中存在差异。将来使用更大样本和不同技术的神经影像学研究可能会阐明妄想症的病因。
方法：20名DD患者和20名健康人纳入研究。苍白无力，壳核,在轴向MRI图像上单独选择尾状核和感兴趣区域（ROI）。应用于所有选择的ROI的整个纹理分析算法是用内部软件完成的。取两侧的核作为单独的样品。
结果：两组之间在年龄和性别方面没有显着差异。平均“意味着，DD患者3个细胞核的中值和最大值均降低.妄想症患者中所有三个核的小壳核面积和在不同组织参数中检测到的差异表明它们在妄想症方面与正常对照不同(p<0.05)。
结论：在所有三个核的质地参数中检测到的差异表明，DD与正常对照中存在差异。将来使用更大样本和不同技术的神经影像学研究可能会阐明妄想症的病因。
