PDF(Pubmed)
Abstract：
BACKGROUND: Although fish oil has been considered to have an anti-inflammatory effect and has been proven to play a beneficial role in the incidence of numerous diseases, the association between fish oil supplementation and the risk of systemic lupus erythematosus (SLE) is still unknown. This study aimed at evaluating the correlation between fish oil use and incident SLE in a large population-based prospective cohort.
METHODS: 390,277 participants without SLE at baseline from the UK Biobank were enrolled. Fish oil use was ascertained through a touchscreen questionnaire at baseline. The incidence of SLE was identified by the International Classification of Diseases version 10 code in medical records or self-report. Cox proportional hazard models were employed to estimate the association between fish oil use and SLE risk.
RESULTS: Fish oil users accounted for 31.47% of participants. During a median follow-up duration of 11.57 years, 141 participants without fish oil use (4.56/100 000 person-years) and 68 participants with fish oil use (4.78/100 000 person-years) developed SLE. In four models with adjustments for different amounts of confounders, there was no significant difference in the risk of SLE between fish oil users and fish oil non-users (all p-values > 0.05). In subgroup analyses, we found that fish oil supplementation was associated with a lower risk of SLE among females with ultraviolet radiation ≥ 3 h/day (hazard ratio: 0.63, 95% confidence interval: 0.40-0.98), which turned insignificant after further adjustment for female-related factors and sun protection measures.
CONCLUSIONS: No significant association between fish oil use and overall incident SLE was observed, except in females exposed to prolonged ultraviolet radiation. Subgroup analysis suggested that females exposed to prolonged ultraviolet radiation might benefit from fish oil supplementation in terms of preventing SLE, but it needs to be confirmed in further studies.
METHODS: 390,277 participants without SLE at baseline from the UK Biobank were enrolled. Fish oil use was ascertained through a touchscreen questionnaire at baseline. The incidence of SLE was identified by the International Classification of Diseases version 10 code in medical records or self-report. Cox proportional hazard models were employed to estimate the association between fish oil use and SLE risk.
RESULTS: Fish oil users accounted for 31.47% of participants. During a median follow-up duration of 11.57 years, 141 participants without fish oil use (4.56/100 000 person-years) and 68 participants with fish oil use (4.78/100 000 person-years) developed SLE. In four models with adjustments for different amounts of confounders, there was no significant difference in the risk of SLE between fish oil users and fish oil non-users (all p-values > 0.05). In subgroup analyses, we found that fish oil supplementation was associated with a lower risk of SLE among females with ultraviolet radiation ≥ 3 h/day (hazard ratio: 0.63, 95% confidence interval: 0.40-0.98), which turned insignificant after further adjustment for female-related factors and sun protection measures.
CONCLUSIONS: No significant association between fish oil use and overall incident SLE was observed, except in females exposed to prolonged ultraviolet radiation. Subgroup analysis suggested that females exposed to prolonged ultraviolet radiation might benefit from fish oil supplementation in terms of preventing SLE, but it needs to be confirmed in further studies.
摘要：
背景：尽管鱼油被认为具有抗炎作用，并且已被证明在众多疾病的发生中起着有益的作用，鱼油补充剂与系统性红斑狼疮(SLE)风险之间的关联尚不清楚.这项研究旨在评估鱼油使用和SLE事件之间的相关性在一个大的人口为基础的前瞻性队列。
方法：390,277名来自英国生物库的基线无SLE的参与者被纳入。在基线时通过触摸屏问卷确定鱼油的使用。SLE的发病率由国际疾病分类第10版代码在医疗记录或自我报告中确定。Cox比例风险模型用于估计鱼油使用与SLE风险之间的关联。
结果：鱼油使用者占参与者的31.47％。在11.57年的中位随访期间，141名没有使用鱼油的参与者（4.56/10万人-年）和68名使用鱼油的参与者（4.78/10万人-年）发展为SLE。在对不同数量的混杂因素进行调整的四个模型中，鱼油使用者与非使用者的SLE风险无显著差异(P值均>0.05)。在亚组分析中，我们发现，补充鱼油与紫外线辐射≥3小时/天的女性SLE风险较低相关（风险比：0.63，95％置信区间：0.40-0.98），在进一步调整女性相关因素和防晒措施后，这一数字变得微不足道。
结论：观察到鱼油使用与整体SLE事件之间没有显着关联，除了长期暴露于紫外线辐射的女性。亚组分析表明，暴露于长时间紫外线辐射的女性可能会从鱼油补充剂中受益，以预防SLE，但需要在进一步的研究中证实。
方法：390,277名来自英国生物库的基线无SLE的参与者被纳入。在基线时通过触摸屏问卷确定鱼油的使用。SLE的发病率由国际疾病分类第10版代码在医疗记录或自我报告中确定。Cox比例风险模型用于估计鱼油使用与SLE风险之间的关联。
结果：鱼油使用者占参与者的31.47％。在11.57年的中位随访期间，141名没有使用鱼油的参与者（4.56/10万人-年）和68名使用鱼油的参与者（4.78/10万人-年）发展为SLE。在对不同数量的混杂因素进行调整的四个模型中，鱼油使用者与非使用者的SLE风险无显著差异(P值均>0.05)。在亚组分析中，我们发现，补充鱼油与紫外线辐射≥3小时/天的女性SLE风险较低相关（风险比：0.63，95％置信区间：0.40-0.98），在进一步调整女性相关因素和防晒措施后，这一数字变得微不足道。
结论：观察到鱼油使用与整体SLE事件之间没有显着关联，除了长期暴露于紫外线辐射的女性。亚组分析表明，暴露于长时间紫外线辐射的女性可能会从鱼油补充剂中受益，以预防SLE，但需要在进一步的研究中证实。
