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Abstract：
BACKGROUND: Obesity is an important risk factor for kidney stones(KS). Chinese Visceral Adiposity Index (CVAI), as a specific indicator for visceral obesity in the Chinese population, can more accurately assess the visceral fat content in Chinese individuals compared to Visceral Adiposity Index (VAI). However, the association between CVAI and risk for KS has not been studied.
METHODS: A total of 97,645 participants from a health screening cohort underwent ultrasound examinations for the diagnosis of kidney stones, along with measurements of their CVAI. Logistic regressions were utilized to determine the relationship between different quartiles of CVAI and the incidence of kidney stones. Simultaneously, subgroup analysis and the computation of dose-response curves were employed to pinpoint susceptible populations.
RESULTS: Among the participants, 2,888 individuals (3.0%) were diagnosed with kidney stones. The mean CVAI values ± standard deviation for the four groups were: Q1 (18.42 ± 19.64), Q2 (65.24 ± 10.39), Q3 (98.20 ± 9.11), and Q4 (140.40 ± 21.73). In the fully adjusted multivariable model, CVAI was positively correlated with urolithiasis (OR = 1.001; 95% CI = 1.000, 1.002). Compared with the first quartile of CVAI, the population in the fourth quartile of CVAI had a higher prevalence of kidney stones (OR = 1.231; 95% CI = 1.066, 1.415). Through subgroup analysis, a positive correlation between CVAI and the risk of kidney stones was found in non-smokers (OR = 1.001, 95%CI:1.000, 1.002), non-drinkers (OR = 1.001, 95%CI:1.000, 1.002), non-hypertensive subgroups (OR = 1.003, 95%CI:1.002, 1.003), and non-diabetes subgroups (OR = 1.001, 95%CI:1.000, 1.002).
CONCLUSIONS: The findings suggest that CVAI could be a reliable and effective biomarker for assessing the potential risk of kidney stone prevalence, with significant implications for the primary prevention of kidney stones and public health.
METHODS: A total of 97,645 participants from a health screening cohort underwent ultrasound examinations for the diagnosis of kidney stones, along with measurements of their CVAI. Logistic regressions were utilized to determine the relationship between different quartiles of CVAI and the incidence of kidney stones. Simultaneously, subgroup analysis and the computation of dose-response curves were employed to pinpoint susceptible populations.
RESULTS: Among the participants, 2,888 individuals (3.0%) were diagnosed with kidney stones. The mean CVAI values ± standard deviation for the four groups were: Q1 (18.42 ± 19.64), Q2 (65.24 ± 10.39), Q3 (98.20 ± 9.11), and Q4 (140.40 ± 21.73). In the fully adjusted multivariable model, CVAI was positively correlated with urolithiasis (OR = 1.001; 95% CI = 1.000, 1.002). Compared with the first quartile of CVAI, the population in the fourth quartile of CVAI had a higher prevalence of kidney stones (OR = 1.231; 95% CI = 1.066, 1.415). Through subgroup analysis, a positive correlation between CVAI and the risk of kidney stones was found in non-smokers (OR = 1.001, 95%CI:1.000, 1.002), non-drinkers (OR = 1.001, 95%CI:1.000, 1.002), non-hypertensive subgroups (OR = 1.003, 95%CI:1.002, 1.003), and non-diabetes subgroups (OR = 1.001, 95%CI:1.000, 1.002).
CONCLUSIONS: The findings suggest that CVAI could be a reliable and effective biomarker for assessing the potential risk of kidney stone prevalence, with significant implications for the primary prevention of kidney stones and public health.
摘要：
背景：肥胖是肾结石（KS）的重要危险因素。中国内脏脂肪指数（CVAI），作为中国人群内脏肥胖的一个具体指标，与内脏脂肪指数（VAI）相比，可以更准确地评估中国人的内脏脂肪含量。然而,CVAI与KS风险之间的关系尚未研究。
方法：来自健康筛查队列的97,645名参与者接受了超声检查以诊断肾结石，以及他们的CVAI测量结果。采用Logistic回归分析确定CVAI不同四分位数与肾结石发生率的关系。同时,亚组分析和剂量反应曲线的计算被用来确定易感人群。
结果：在参与者中，2,888人（3.0％）被诊断为肾结石。四组的平均CVAI值±标准偏差为：Q1（18.42±19.64），Q2(65.24±10.39),Q3(98.20±9.11),和Q4（140.40±21.73）。在完全调整的多变量模型中，CVAI与尿石症呈正相关(OR=1.001;95%CI=1.000,1.002)。与CVAI的第一个四分位数相比，CVAI第4四分位数人群的肾结石患病率较高(OR=1.231;95%CI=1.066,1.415).通过亚组分析，在非吸烟者中发现CVAI与肾结石风险之间呈正相关（OR=1.001，95CI：1.000，1.002），非饮酒者（OR=1.001，95CI：1.000，1.002），非高血压亚组（OR=1.003，95CI：1.002，1.003），和非糖尿病亚组（OR=1.001，95CI：1.000，1.002）。
结论：研究结果表明，CVAI可能是评估肾结石患病率潜在风险的可靠且有效的生物标志物。对肾结石的一级预防和公共卫生具有重要意义。
方法：来自健康筛查队列的97,645名参与者接受了超声检查以诊断肾结石，以及他们的CVAI测量结果。采用Logistic回归分析确定CVAI不同四分位数与肾结石发生率的关系。同时,亚组分析和剂量反应曲线的计算被用来确定易感人群。
结果：在参与者中，2,888人（3.0％）被诊断为肾结石。四组的平均CVAI值±标准偏差为：Q1（18.42±19.64），Q2(65.24±10.39),Q3(98.20±9.11),和Q4（140.40±21.73）。在完全调整的多变量模型中，CVAI与尿石症呈正相关(OR=1.001;95%CI=1.000,1.002)。与CVAI的第一个四分位数相比，CVAI第4四分位数人群的肾结石患病率较高(OR=1.231;95%CI=1.066,1.415).通过亚组分析，在非吸烟者中发现CVAI与肾结石风险之间呈正相关（OR=1.001，95CI：1.000，1.002），非饮酒者（OR=1.001，95CI：1.000，1.002），非高血压亚组（OR=1.003，95CI：1.002，1.003），和非糖尿病亚组（OR=1.001，95CI：1.000，1.002）。
结论：研究结果表明，CVAI可能是评估肾结石患病率潜在风险的可靠且有效的生物标志物。对肾结石的一级预防和公共卫生具有重要意义。
