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Abstract：
This study aimed to retrospectively examine the computed tomography (CT) features of lung adenocarcinoma across different demographic groups. Preoperative chest CT findings from 1266 surgically resected lung adenocarcinoma cases were retrospectively analyzed. Lung adenocarcinomas were categorized based on CT characteristics into pure ground glass (pGGO), nodule-containing ground glass opacity (mGGO), and pure solid without containing ground glass opacity (pSD). These categories were correlated with sex, age, EGFR status, and five histopathological subtypes. The diameters of pGGO, mGGO, and pSD significantly increased across all patient groups (P < 0.05). Males exhibited a significantly higher proportion of pSD than females (P = 0.002). The mean diameters of pGGO and pSD were significantly larger in males than in females (P = 0.0017 and P = 0.043, respectively). The frequency of pGGO was higher in the younger age group (≤ 60 years) compared to the older group (> 60 years) for both males (P = 0.002) and females (P = 0.027). The frequency of pSD was higher in the older age group for both sexes. A linear correlation between age and diameter was observed in the entire cohort as well as in the male and female groups (P < 0.0001 for all groups). EGFR mutations were less frequent in pSD compared to pGGO (P = 0.0002) and mGGO (P < 0.0001). The frequency of lesions containing micropapillary components increased from pGGO to mGGO and pSD (P < 0.0001 for all). The frequency of lesions containing solid components also increased from pGGO to mGGO and pSD (P = 0.045, P < 0.0001, and P < 0.0001, respectively). The CT features of lung adenocarcinoma exhibit differences across genders and age groups. Male gender and older age are risk factors for lung adenocarcinoma growth.
摘要：
这项研究旨在回顾性检查不同人口统计学群体的肺腺癌的计算机断层扫描（CT）特征。回顾性分析1266例手术切除的肺腺癌患者的术前胸部CT表现。根据CT特征将肺腺癌分为纯磨玻璃（pGGO），含结节的毛玻璃不透明度（mGGO），和纯固体，不含毛玻璃不透明度（pSD）。这些类别与性别相关，年龄,EGFR状态，和五种组织病理学亚型。PGGO的直径，mGGO,pSD在所有患者组中显著增加(P<0.05)。男性的pSD比例明显高于女性（P=0.002）。男性pGGO和pSD的平均直径明显大于女性（分别为P=0.0017和P=0.043）。对于男性（P=0.002）和女性（P=0.027），年轻年龄组（≤60岁）的pGGO频率高于老年组（>60岁）。男女年龄较大的年龄组中pSD的频率较高。在整个队列以及男性和女性组中观察到年龄和直径之间的线性相关性（所有组的P<0.0001）。与pGGO（P=0.0002）和mGGO（P<0.0001）相比，pSD中的EGFR突变频率较低。包含微乳头状成分的病变频率从pGGO增加到mGGO和pSD（均P<0.0001）。包含固体成分的病变的频率也从pGGO增加到mGGO和pSD（分别为P=0.045，P<0.0001和P<0.0001）。肺腺癌的CT特征在性别和年龄组之间表现出差异。男性和年龄较大是肺腺癌生长的危险因素。
