Abstract：
UNASSIGNED: This study aimed to investigate the feasibility, efficacy, and safety of focused ultrasound (FUS) for the treatment of vulvar low-grade squamous intraepithelial lesions (VLSIL) with persistent symptoms.
UNASSIGNED: This retrospective analysis included 24 VLSIL patients who underwent FUS treatment. At each follow-up visit, the clinical response was assessed including changes in symptoms and signs. In addition, the histological response was assessed based on the vulvar biopsy results of the 3rd follow-up. Clinical and histological response were assessed to elucidate the efficacy.
UNASSIGNED: A total of 22 patients completed follow-up and post-treatment pathological biopsies. After treatment, the clinical scores of itching decreased from 2.55 ± 0.51 to 0.77 ± 0.81 (p < 0.05). Furthermore, the clinical response rate and histological response rate were 86.4% and 81.8%, respectively. Only two cured patients indicated recurrence in the 3rd and 4th year during the follow-up period and achieved cure after re-treatment. In terms of adverse effects, only one patient developed ulcers after treatment, which healed after symptomatic anti-inflammatory treatment without scarring, and no other treatment complications were found in any patients. None of the patients developed a malignant transformation during the follow-up period.
UNASSIGNED: This study revealed that FUS is feasible, effective, and safe for treating VLSIL patients with persistent symptoms, providing a new solution for the noninvasive treatment of symptomatic VLSIL.
UNASSIGNED: This retrospective analysis included 24 VLSIL patients who underwent FUS treatment. At each follow-up visit, the clinical response was assessed including changes in symptoms and signs. In addition, the histological response was assessed based on the vulvar biopsy results of the 3rd follow-up. Clinical and histological response were assessed to elucidate the efficacy.
UNASSIGNED: A total of 22 patients completed follow-up and post-treatment pathological biopsies. After treatment, the clinical scores of itching decreased from 2.55 ± 0.51 to 0.77 ± 0.81 (p < 0.05). Furthermore, the clinical response rate and histological response rate were 86.4% and 81.8%, respectively. Only two cured patients indicated recurrence in the 3rd and 4th year during the follow-up period and achieved cure after re-treatment. In terms of adverse effects, only one patient developed ulcers after treatment, which healed after symptomatic anti-inflammatory treatment without scarring, and no other treatment complications were found in any patients. None of the patients developed a malignant transformation during the follow-up period.
UNASSIGNED: This study revealed that FUS is feasible, effective, and safe for treating VLSIL patients with persistent symptoms, providing a new solution for the noninvasive treatment of symptomatic VLSIL.
摘要：
■本研究旨在探讨可行性，功效,聚焦超声（FUS）治疗伴有持续症状的外阴低度鳞状上皮内病变（VLSIL）的安全性。
■这项回顾性分析包括24例接受FUS治疗的VLSIL患者。在每次后续访问中，评估了临床反应,包括症状和体征的变化.此外,根据第3次随访的外阴活检结果评估组织学反应.评估临床和组织学反应以阐明功效。
■共有22名患者完成了随访和治疗后的病理活检。治疗后,瘙痒的临床评分从2.55±0.51降至0.77±0.81（p<0.05）。此外，临床有效率和组织学有效率分别为86.4%和81.8%，分别。只有2例治愈的患者在随访期间第3年和第4年复发，并在再次治疗后治愈。在不利影响方面，只有一名患者在治疗后出现溃疡，对症抗炎治疗后愈合，没有疤痕，在任何患者中均未发现其他治疗并发症。在随访期间，没有患者发生恶性转化。
■这项研究表明FUS是可行的，有效,并且可以安全地治疗具有持续症状的VLSIL患者，为有症状的VLSIL的无创治疗提供了新的解决方案。
■这项回顾性分析包括24例接受FUS治疗的VLSIL患者。在每次后续访问中，评估了临床反应,包括症状和体征的变化.此外,根据第3次随访的外阴活检结果评估组织学反应.评估临床和组织学反应以阐明功效。
■共有22名患者完成了随访和治疗后的病理活检。治疗后,瘙痒的临床评分从2.55±0.51降至0.77±0.81（p<0.05）。此外，临床有效率和组织学有效率分别为86.4%和81.8%，分别。只有2例治愈的患者在随访期间第3年和第4年复发，并在再次治疗后治愈。在不利影响方面，只有一名患者在治疗后出现溃疡，对症抗炎治疗后愈合，没有疤痕，在任何患者中均未发现其他治疗并发症。在随访期间，没有患者发生恶性转化。
■这项研究表明FUS是可行的，有效,并且可以安全地治疗具有持续症状的VLSIL患者，为有症状的VLSIL的无创治疗提供了新的解决方案。
