关键词: Ear, nose and throat/otolaryngology Oncology Thyroid Gland

Mesh : Humans Female Thyroid Neoplasms / pathology diagnosis surgery Thymus Neoplasms / surgery diagnosis complications diagnostic imaging pathology Thyroidectomy Adult Biopsy, Fine-Needle Thymoma / pathology surgery diagnostic imaging diagnosis complications Neck Dissection Radiotherapy, Adjuvant Diagnosis, Differential Hoarseness / etiology

来  源:   DOI:10.1136/bcr-2024-260938

Abstract:
A young woman in her early 30s presented with a right thyroid mass and progressive hoarseness due to a right vocal cord palsy. The preoperative fine-needle aspiration cytology was classified as Bethesda V and she underwent a total thyroidectomy and neck dissection. Intraoperatively, the thyroid mass was adherent to the oesophagus, trachea and encasing the right recurrent laryngeal nerve which was sacrificed. Final histopathology diagnosed a rare subtype of thyroid cancer known as intrathyroidal thymic carcinoma (ITC). She was then sent for adjuvant radiotherapy after a multidisciplinary tumour board discussion. This case report highlights the difficulty in preoperative diagnosis of ITC and the importance of immunohistochemical staining in clinching the diagnosis. In view of its rarity, there have been no published consensus on the treatment of ITC, hence we would like to share some learning points through a comprehensive literature review.
摘要:
一名30多岁的年轻女子由于右声带麻痹而出现右甲状腺肿块和进行性声音嘶哑。术前细针抽吸细胞学检查被分类为BethesdaV,她接受了全甲状腺切除术和颈部清扫术。术中,甲状腺块粘附在食管上,气管和包裹被处死的右喉返神经。最终的组织病理学诊断为一种罕见的甲状腺癌亚型,称为甲状腺内胸腺癌(ITC)。在多学科肿瘤委员会讨论后,她被送去接受辅助放射治疗。该病例报告强调了ITC术前诊断的困难以及免疫组织化学染色在诊断中的重要性。鉴于其稀有性,关于ITC的治疗没有公开的共识,因此,我们想通过全面的文献综述分享一些学习要点。
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