PDF(Pubmed)
Abstract：
The intricate molecular and structural sequences guiding the formation and consolidation of memories within neuronal circuits remain largely elusive. In this study, we investigate the roles of two pivotal presynaptic regulators, the small GTPase Rab3, enriched at synaptic vesicles, and the cell adhesion protein Neurexin-1, in the formation of distinct memory phases within the Drosophila mushroom body Kenyon cells. Our findings suggest that both proteins play crucial roles in memory-supporting processes within the presynaptic terminal, operating within distinct plasticity modules. These modules likely encompass remodeling and maturation of existing active zones (AZs), as well as the formation of new AZs.
摘要：
指导神经元回路中记忆的形成和巩固的复杂分子和结构序列在很大程度上仍然难以捉摸。在这项研究中,我们研究了两种关键的突触前调节剂的作用，小GTP酶Rab3，富集在突触小泡，和细胞粘附蛋白Neurexin-1，在果蝇蘑菇体Kenyon细胞内形成不同的记忆阶段。我们的发现表明，这两种蛋白质在突触前末端的记忆支持过程中起着至关重要的作用。在不同的可塑性模块内运行。这些模块可能包括现有活动区(AZ)的重塑和成熟，以及新AZs的形成。
