Abstract：
BACKGROUND: Spine stereotactic body radiation therapy (SBRT) for the treatment of metastatic disease is increasingly utilized owing to improved pain and local control over conventional regimens. Vertebral body collapse (VBC) is an important toxicity following spine SBRT. We investigated our institutional experience with spine SBRT as it relates to VBC and spinal instability neoplastic score (SINS).
METHODS: Records of 83 patients with 100 spinal lesions treated with SBRT between 2007 and 2022 were reviewed. Clinical information was abstracted from the medical record. The primary endpoint was post-treatment VBC. Logistic univariate analysis was performed to identify clinical factors associated with VBC.
RESULTS: Median dose and number of fractions used was 24 Gy and 3 fractions, respectively. There were 10 spine segments that developed VBC (10%) after spine SBRT. Median time to VBC was 2.4 months. Of the 11 spine segments that underwent kyphoplasty prior to SBRT, none developed subsequent VBC. No factors were associated with VBC on univariate analysis.
CONCLUSIONS: The rate of vertebral body collapse following spine SBRT is low. Prophylactic kyphoplasty may provide protection against VBC and should be considered for patients at high risk for fracture.
METHODS: Records of 83 patients with 100 spinal lesions treated with SBRT between 2007 and 2022 were reviewed. Clinical information was abstracted from the medical record. The primary endpoint was post-treatment VBC. Logistic univariate analysis was performed to identify clinical factors associated with VBC.
RESULTS: Median dose and number of fractions used was 24 Gy and 3 fractions, respectively. There were 10 spine segments that developed VBC (10%) after spine SBRT. Median time to VBC was 2.4 months. Of the 11 spine segments that underwent kyphoplasty prior to SBRT, none developed subsequent VBC. No factors were associated with VBC on univariate analysis.
CONCLUSIONS: The rate of vertebral body collapse following spine SBRT is low. Prophylactic kyphoplasty may provide protection against VBC and should be considered for patients at high risk for fracture.
摘要：
背景：由于与常规方案相比改善了疼痛和局部控制，因此用于治疗转移性疾病的脊柱立体定向放射治疗（SBRT）越来越多地被使用。椎体塌陷（VBC）是脊柱SBRT后的重要毒性。我们调查了我们在脊柱SBRT方面的机构经验，因为它与VBC和脊柱不稳定肿瘤评分（SINS）有关。
方法：回顾了2007年至2022年间83例接受SBRT治疗的100例脊柱病变患者的记录。从病历中提取临床信息。主要终点为治疗后VBC。进行Logistic单因素分析以确定与VBC相关的临床因素。
结果：使用的剂量和分数的中位数为24Gy和3个分数，分别。脊柱SBRT后有10个脊柱节段发生VBC（10％）。VBC的中位时间为2.4个月。在SBRT之前接受椎体后凸成形术的11个脊柱节段中，没有发生随后的VBC。单因素分析与VBC无相关性。
结论：脊柱SBRT后椎体塌陷率较低。预防性椎体后凸成形术可以提供对VBC的保护，对于骨折高危患者应考虑。
方法：回顾了2007年至2022年间83例接受SBRT治疗的100例脊柱病变患者的记录。从病历中提取临床信息。主要终点为治疗后VBC。进行Logistic单因素分析以确定与VBC相关的临床因素。
结果：使用的剂量和分数的中位数为24Gy和3个分数，分别。脊柱SBRT后有10个脊柱节段发生VBC（10％）。VBC的中位时间为2.4个月。在SBRT之前接受椎体后凸成形术的11个脊柱节段中，没有发生随后的VBC。单因素分析与VBC无相关性。
结论：脊柱SBRT后椎体塌陷率较低。预防性椎体后凸成形术可以提供对VBC的保护，对于骨折高危患者应考虑。
