肾癌中 rapalogs 的非常规作用机制和耐药性。
关键词: Cancer-associated fibroblasts (CAFs) everolimus kinase inhibitors patient-derived xenograft (PDX) temsirolimus
Mesh : Animals Kidney Neoplasms / genetics metabolism drug therapy pathology Carcinoma, Renal Cell / genetics drug therapy metabolism pathology Mice Humans Drug Resistance, Neoplasm / genetics drug effects Mechanistic Target of Rapamycin Complex 1 / metabolism TOR Serine-Threonine Kinases / metabolism Tumor Microenvironment / drug effects Cell Line, Tumor Sirolimus / pharmacology Mutation MTOR Inhibitors / pharmacology therapeutic use
来 源:
DOI:10.1073/pnas.2310793121
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