Abstract：
There is a potential link between cannabis and mental disorders. Cannabis exposure involves in many cases negative mental emotions, which are unpleasant sensations or thoughts. Whereas mild cases of negative mental emotions inflict patient\'s quality of life, more severe cases lead to therapy discontinuations, or even hospitalizations and death. This study characterizes cannabis users who experienced negative mental emotions after cannabis exposure. The Releaf App database was utilized to evaluate the association between personal and cannabis use characteristics on reporting a negative mental emotion during cannabis exposure. This global mobile lets individuals track real-time cannabis experience use with cannabinoid-based products, containing data points such as gender, age, reasons for use, product type, cannabis composition, and feelings and emotions experienced after cannabis use. Multivariable logistic regression models were constructed, adjusting for potential confounders such as gender and previous experience with cannabis use. The study population comprised 4,435 users, and 34,279 sessions were collected from various countries, mainly from North America, and included in the primary analysis. Reporting on negative mental emotions was associated with users in the age group of 18-30 years. Using cannabis for a mental purpose was associated with a small increase in reporting on negative mental emotions (OR = 1.10, 95%CI [1.03-1.19]). Oral products were associated with reporting on negative mental emotions. THC-dominant products were associated with reporting negative mental emotions compared to balanced products (OR = 1.21, 95%CI [1.06-1.38]). This study suggests that some characteristics of cannabis use, such as young age and oral consumption are associated with negative mental emotions. Further studies should examine the interface between cannabis consumption, characteristics of consumers, and negative emotional experience or even long-term mental disorders.
摘要：
大麻与精神障碍之间存在潜在联系。在许多情况下，大麻暴露涉及负面的心理情绪，是不愉快的感觉或想法。而轻微的负面情绪会影响患者的生活质量，更严重的病例导致治疗中断，甚至住院和死亡。这项研究描述了大麻暴露后经历负面心理情绪的大麻使用者。ReleafApp数据库用于评估个人与大麻使用特征之间的关联，以报告大麻暴露期间的负面心理情绪。该全球移动设备可让个人跟踪基于大麻素的产品的实时大麻使用体验，包含性别等数据点，年龄,使用理由,产品类型,大麻成分,以及使用大麻后经历的感觉和情绪。建立多变量Logistic回归模型，调整潜在的混杂因素，如性别和以前使用大麻的经验。研究人群包括4,435名用户，从各国收集了34,279次会议，主要来自北美，并包括在初步分析中。负面情绪的报告与18-30岁年龄段的用户有关。出于精神目的使用大麻与负面心理情绪报告的小幅增加有关（OR=1.10，95CI[1.03-1.19]）。口服产品与负面心理情绪的报告有关。与平衡产品相比，THC主导产品与报告负面心理情绪相关(OR=1.21,95CI[1.06-1.38])。这项研究表明，大麻使用的一些特征，例如年轻的年龄和口服消费与负面的心理情绪有关。进一步的研究应该检查大麻消费之间的接口，消费者的特点，和负面的情绪体验甚至是长期的精神障碍。
