Abstract：
The use of negative pressure wound therapy with instillation and dwell time (NPWTi-d) has been shown to be effective in removing nonviable tissue, reducing bioburden, and promoting granulation tissue formation in acute and chronic infected wounds.
To illustrate the clinical efficacy of the use of pure hypochlorous acid (pHA) antimicrobially preserved wound cleansing solution as the instillation fluid for NPWTi-d (NPWTi-d/pHA) in wound bed preparation in patients with complex wounds.
The treatment protocol for use of NPWTi-d/pHA in preparing wound beds for final closure is demonstrated in 3 illustrative cases of patients with complex wounds resulting from necrotizing infection and trauma with heavy contamination. All 3 patients developed a healthy-appearing wound bed deemed suitable for primary closure an average of approximately 1 month following initial surgical debridement.
The cases presented demonstrate the ability of a pHA antimicrobially preserved wound cleansing solution used as the instillation fluid with NPWTi-d to aid in bacterial reduction, mechanical debridement, and promotion of wound healing. Use of NPWTi-d/pHA in these cases of extensive necrotizing infection and posttraumatic injury with heavy contamination allowed for final closure an average of 1 month after initial surgical debridement.
To illustrate the clinical efficacy of the use of pure hypochlorous acid (pHA) antimicrobially preserved wound cleansing solution as the instillation fluid for NPWTi-d (NPWTi-d/pHA) in wound bed preparation in patients with complex wounds.
The treatment protocol for use of NPWTi-d/pHA in preparing wound beds for final closure is demonstrated in 3 illustrative cases of patients with complex wounds resulting from necrotizing infection and trauma with heavy contamination. All 3 patients developed a healthy-appearing wound bed deemed suitable for primary closure an average of approximately 1 month following initial surgical debridement.
The cases presented demonstrate the ability of a pHA antimicrobially preserved wound cleansing solution used as the instillation fluid with NPWTi-d to aid in bacterial reduction, mechanical debridement, and promotion of wound healing. Use of NPWTi-d/pHA in these cases of extensive necrotizing infection and posttraumatic injury with heavy contamination allowed for final closure an average of 1 month after initial surgical debridement.
摘要：
背景：使用负压伤口治疗滴注和停留时间（NPWTi-d）已被证明可有效去除无活力组织，减少生物负载，并促进急性和慢性感染伤口中肉芽组织的形成。
目的：说明使用纯次氯酸（pHA）抗菌保存的伤口清洗液作为NPWTi-d（NPWTi-d/pHA）滴注液在复杂伤口患者伤口床准备中的临床疗效。
方法：使用NPWTi-d/pHA制备最终闭合伤口床的治疗方案在3例示例性病例中得到了证明，这些患者具有由坏死性感染和重度污染造成的复杂伤口。所有3名患者在初始手术清创后平均约1个月出现了看起来健康的伤口床，被认为适合初次闭合。
结论：所介绍的病例证明了pHA抗菌保存的伤口清洁液作为NPWTi-d滴注液有助于减少细菌的能力，机械清创,促进伤口愈合。在这些广泛的坏死性感染和严重污染的创伤后损伤的情况下，使用NPWTi-d/pHA可以在初次手术清创后平均1个月内最终闭合。
目的：说明使用纯次氯酸（pHA）抗菌保存的伤口清洗液作为NPWTi-d（NPWTi-d/pHA）滴注液在复杂伤口患者伤口床准备中的临床疗效。
方法：使用NPWTi-d/pHA制备最终闭合伤口床的治疗方案在3例示例性病例中得到了证明，这些患者具有由坏死性感染和重度污染造成的复杂伤口。所有3名患者在初始手术清创后平均约1个月出现了看起来健康的伤口床，被认为适合初次闭合。
结论：所介绍的病例证明了pHA抗菌保存的伤口清洁液作为NPWTi-d滴注液有助于减少细菌的能力，机械清创,促进伤口愈合。在这些广泛的坏死性感染和严重污染的创伤后损伤的情况下，使用NPWTi-d/pHA可以在初次手术清创后平均1个月内最终闭合。
