Abstract：
The synthesis of a water-soluble, phosphine-pegylated iridium(I) catalyst and its application in hydrogen isotope exchange (HIE) reactions in buffer is reported. The longer polyethylene glycol side chains on the phosphine increased the water solubility independently from the pH. HIE reactions of polar substrates in protic solvents were studied. DFT calculations gave further insights into the catalytic processes. The scope and limitation of the pegylated catalyst was studied in HIE reactions of several complex compounds in borax buffer at pH 9 and the best conditions were applied in a tritium experiment with the drug telmisartan.
摘要：
合成了一种水溶性,报道了膦-聚乙二醇化铱（I）催化剂及其在缓冲液中氢同位素交换（HIE）反应中的应用。膦上更长的聚乙二醇侧链增加了水溶性,与pH无关。研究了极性底物在质子溶剂中的HIE反应。DFT计算为催化过程提供了进一步的内部因素。研究了聚乙二醇化催化剂在pH9的硼砂缓冲液中几种复杂化合物的HIE反应中的范围和局限性，并将最佳条件应用于药物替米沙坦的tri实验中。
