PDF(Pubmed)
Abstract：
Macrophages play crucial and versatile roles in regulating tissue repair and regeneration upon injury. However, due to their complex compositional heterogeneity and functional plasticity, deciphering the nature of different macrophage subpopulations and unraveling their dynamics and precise roles during the repair process have been challenging. With its distinct advantages, zebrafish (Danio rerio) has emerged as an invaluable model for studying macrophage development and functions, especially in tissue repair and regeneration, providing valuable insights into our understanding of macrophage biology in health and diseases. In this review, we present the current knowledge and challenges associated with the role of macrophages in tissue repair and regeneration, highlighting the significant contributions made by zebrafish studies. We discuss the unique advantages of the zebrafish model, including its genetic tools, imaging techniques, and regenerative capacities, which have greatly facilitated the investigation of macrophages in these processes. Additionally, we outline the potential of zebrafish research in addressing the remaining challenges and advancing our understanding of the intricate interplay between macrophages and tissue repair and regeneration.
摘要：
巨噬细胞在调节损伤后的组织修复和再生中起着至关重要的作用。然而,由于它们复杂的成分异质性和功能可塑性，破译不同巨噬细胞亚群的性质，并揭示它们在修复过程中的动力学和精确作用一直具有挑战性。凭借其独特的优势，斑马鱼（Daniorerio）已成为研究巨噬细胞发育和功能的宝贵模型，特别是在组织修复和再生方面，为我们对健康和疾病中巨噬细胞生物学的理解提供有价值的见解。在这次审查中,我们介绍了目前与巨噬细胞在组织修复和再生中的作用相关的知识和挑战，强调斑马鱼研究的重大贡献。我们讨论了斑马鱼模型的独特优势，包括它的遗传工具，成像技术，和再生能力，这极大地促进了巨噬细胞在这些过程中的研究。此外,我们概述了斑马鱼研究在解决剩余挑战和提高我们对巨噬细胞与组织修复和再生之间复杂相互作用的理解方面的潜力.
