Abstract：
The repurposing of existing drugs, referred to as theranostics, has made profound impacts on precision medicine. Indocyanine green (ICG), a well-established and clinical dye, has continued to be a star agent, described as a multifunctional molecule with concurrent photo- or sono-sensitiveness capabilities and co-delivery accessibility, showing remarkable potential in the area of unimodal or multimodal imaging-guided therapy of various diseases, leading to the extensive consideration of immediate clinical translations. In this review, we strive to bring the understanding of repurposing performance assessment for ICG into practice by clarifying the relationships between its features and applicability. Specifically, we address the obstacles encountered in the process of developing an ICG repurposing strategy, as well as the noteworthy advancements made in the field of ICG repurposing. We also go into detail about the structure-function correlations of drugs containing ICG and how different structural groups significantly affect the physicochemical properties.
摘要：
现有药物的再利用，被称为治疗，对精准医学产生了深远的影响。吲哚菁绿(ICG),一种成熟的临床染料，一直是明星特工,描述为具有并发光或声敏感能力和共同递送可及性的多功能分子，在各种疾病的单峰或多模态成像引导治疗领域显示出巨大的潜力，导致对立即临床翻译的广泛考虑。在这次审查中,我们努力通过澄清ICG的特征和适用性之间的关系，将对ICG绩效评估重新利用的理解付诸实践。具体来说,我们解决了在制定ICG重新利用战略过程中遇到的障碍，以及在ICG重新利用领域取得的值得注意的进展。我们还详细介绍了含有ICG的药物的结构-功能相关性以及不同结构基团如何显着影响理化性质。
