Abstract：
OBJECTIVE: This retrospective observational cohort study aimed to compare clinical characteristics and treatment responses in patients exclusively experiencing unifocal nummular headache (NH) with those who develop the bifocal variant.
METHODS: A retrospective study was conducted on patients diagnosed with NH who attended a neurology (headache) outpatient clinic between January 2018 and December 2022. The cohort was divided into two groups: Group 1, exclusive unifocal NH; and Group 2, those developing a secondary focal area of pain, i.e., bifocal NH. Data were collected on demographic characteristics, clinical features, other headache comorbidities, and treatment-related information.
RESULTS: A total of 23 patients were included in this study: 12 were categorized as unifocal NH (Group 1) and 11 as bifocal NH (Group 2). There were no differences between the two groups in terms of demographic characteristics, clinical features, or treatment response. Nonetheless, patients with bifocal NH exhibited spontaneous remission rates in the first pain area when compared to the unifocal NH group, with statistically significant differences (36% vs. 0%, p = 0.020).
CONCLUSIONS: In our sample, patients with bifocal NH demonstrated spontaneous remission rates in the initial pain area, a phenomenon not observed in patients with unifocal NH. It is worth noting the limited sample size in the present study, highlighting the need for larger cohorts to validate and further explore our findings.
METHODS: A retrospective study was conducted on patients diagnosed with NH who attended a neurology (headache) outpatient clinic between January 2018 and December 2022. The cohort was divided into two groups: Group 1, exclusive unifocal NH; and Group 2, those developing a secondary focal area of pain, i.e., bifocal NH. Data were collected on demographic characteristics, clinical features, other headache comorbidities, and treatment-related information.
RESULTS: A total of 23 patients were included in this study: 12 were categorized as unifocal NH (Group 1) and 11 as bifocal NH (Group 2). There were no differences between the two groups in terms of demographic characteristics, clinical features, or treatment response. Nonetheless, patients with bifocal NH exhibited spontaneous remission rates in the first pain area when compared to the unifocal NH group, with statistically significant differences (36% vs. 0%, p = 0.020).
CONCLUSIONS: In our sample, patients with bifocal NH demonstrated spontaneous remission rates in the initial pain area, a phenomenon not observed in patients with unifocal NH. It is worth noting the limited sample size in the present study, highlighting the need for larger cohorts to validate and further explore our findings.
摘要：
目的：这项回顾性观察性队列研究旨在比较单发性头痛（NH）患者和双病灶性头痛患者的临床特征和治疗反应。
方法：对2018年1月至2022年12月在神经科（头痛）门诊就诊的被诊断为NH的患者进行了回顾性研究。该队列分为两组：第1组，唯一的单灶性NH；和第2组，发展为继发性局灶性疼痛区域，即，双焦NH.收集了有关人口统计特征的数据，临床特征,其他头痛合并症，和治疗相关的信息。
结果：本研究共纳入23例患者：12例分为单焦点NH（第1组），11例分为双焦点NH（第2组）。两组在人口统计学特征方面没有差异,临床特征,或治疗反应。尽管如此，与单焦点NH组相比，双焦点NH患者在第一疼痛区域表现出自发缓解率，具有统计学上的显著差异(36%与0%,p=0.020)。
结论：在我们的样本中，双焦点NH患者在初始疼痛区域表现出自发缓解率，在单局部NH患者中未观察到的现象。值得注意的是，本研究的样本量有限，强调需要更大的队列来验证和进一步探索我们的发现。
方法：对2018年1月至2022年12月在神经科（头痛）门诊就诊的被诊断为NH的患者进行了回顾性研究。该队列分为两组：第1组，唯一的单灶性NH；和第2组，发展为继发性局灶性疼痛区域，即，双焦NH.收集了有关人口统计特征的数据，临床特征,其他头痛合并症，和治疗相关的信息。
结果：本研究共纳入23例患者：12例分为单焦点NH（第1组），11例分为双焦点NH（第2组）。两组在人口统计学特征方面没有差异,临床特征,或治疗反应。尽管如此，与单焦点NH组相比，双焦点NH患者在第一疼痛区域表现出自发缓解率，具有统计学上的显著差异(36%与0%,p=0.020)。
结论：在我们的样本中，双焦点NH患者在初始疼痛区域表现出自发缓解率，在单局部NH患者中未观察到的现象。值得注意的是，本研究的样本量有限，强调需要更大的队列来验证和进一步探索我们的发现。
