Abstract：
OBJECTIVE: To analyze oncological efficacy and voice outcomes of the 445-nm blue laser (BL) in the treatment of early glottic carcinoma and compare results with the 532-nm potassium-titanyl-phosphate (KTP) laser.
METHODS: Single institution, retrospective chart review.
METHODS: All patients who underwent microlaryngoscopic KTP or BL laser excision of early glottic carcinoma from 2018 to the present day with at least 1-year follow-up were included. Primary and recurrent disease, including radiation and surgical failures, were included. Demographic data, voice outcomes and oncologic outcomes were compared between the two laser groups.
RESULTS: Forty-nine patients met the inclusion criteria for the BL group and 88 for the KTP group, with average follow-up of 635 and 1236 days, respectively. Oncologic outcomes were not significantly different, with disease-specific survival rates of 95.9% for BL and 100% for KTP (p = 0.13), organ preservation rates of 98.0% for BL and 95.6% for KTP (p = 0.39), and local control rates of 93.9% for BL and 92.1% for KTP (p = 0.81). Both BL and KTP groups showed significant improvement in CAPE-V (p = 0.04, 0.006 respectively) and VHI-10 scores (p = 0.003, <0.00001) following surgery.
CONCLUSIONS: Photoangiolytic removal of early glottic carcinoma with BL appears to be equally safe and effective as with KTP laser at minimum one-year follow-up, and with excellent voice outcomes. Additional study will be warranted over time to assess long-term outcomes in BL patients.
METHODS: 3 Laryngoscope, 2024.
METHODS: Single institution, retrospective chart review.
METHODS: All patients who underwent microlaryngoscopic KTP or BL laser excision of early glottic carcinoma from 2018 to the present day with at least 1-year follow-up were included. Primary and recurrent disease, including radiation and surgical failures, were included. Demographic data, voice outcomes and oncologic outcomes were compared between the two laser groups.
RESULTS: Forty-nine patients met the inclusion criteria for the BL group and 88 for the KTP group, with average follow-up of 635 and 1236 days, respectively. Oncologic outcomes were not significantly different, with disease-specific survival rates of 95.9% for BL and 100% for KTP (p = 0.13), organ preservation rates of 98.0% for BL and 95.6% for KTP (p = 0.39), and local control rates of 93.9% for BL and 92.1% for KTP (p = 0.81). Both BL and KTP groups showed significant improvement in CAPE-V (p = 0.04, 0.006 respectively) and VHI-10 scores (p = 0.003, <0.00001) following surgery.
CONCLUSIONS: Photoangiolytic removal of early glottic carcinoma with BL appears to be equally safe and effective as with KTP laser at minimum one-year follow-up, and with excellent voice outcomes. Additional study will be warranted over time to assess long-term outcomes in BL patients.
METHODS: 3 Laryngoscope, 2024.
摘要：
目的：分析445nm蓝光激光（BL）治疗早期声门型喉癌的疗效和嗓音结果，并与532nm磷酸钾钛（KTP）激光的结果进行比较。
方法：单一机构，回顾性图表审查。
方法：纳入2018年至今接受显微喉镜KTP或BL激光早期声门癌切除术并至少随访1年的所有患者。原发性和复发性疾病，包括放射和手术失败,包括在内。人口统计数据,比较了两组激光组的语音结局和肿瘤结局.
结果：49例符合纳入标准的患者为BL组，88例符合纳入标准的患者为KTP组，平均随访635天和1236天，分别。肿瘤学结果没有显着差异，BL和KTP的疾病特异性生存率分别为95.9%和100%（p=0.13），BL器官保存率为98.0％，KTP为95.6％（p=0.39），BL和KTP的局部控制率分别为93.9%和92.1%(p=0.81)。BL和KTP组均显示出手术后CAPE-V（分别为p=0.04，0.006）和VHI-10评分（p=0.003，<0.00001）的显着改善。
结论：在至少一年的随访中，对BL早期声门型喉癌进行光血管溶解切除似乎与KTP激光一样安全有效，并具有出色的语音结果。随着时间的推移，将需要额外的研究来评估BL患者的长期结果。
方法：3喉镜，2024.
方法：单一机构，回顾性图表审查。
方法：纳入2018年至今接受显微喉镜KTP或BL激光早期声门癌切除术并至少随访1年的所有患者。原发性和复发性疾病，包括放射和手术失败,包括在内。人口统计数据,比较了两组激光组的语音结局和肿瘤结局.
结果：49例符合纳入标准的患者为BL组，88例符合纳入标准的患者为KTP组，平均随访635天和1236天，分别。肿瘤学结果没有显着差异，BL和KTP的疾病特异性生存率分别为95.9%和100%（p=0.13），BL器官保存率为98.0％，KTP为95.6％（p=0.39），BL和KTP的局部控制率分别为93.9%和92.1%(p=0.81)。BL和KTP组均显示出手术后CAPE-V（分别为p=0.04，0.006）和VHI-10评分（p=0.003，<0.00001）的显着改善。
结论：在至少一年的随访中，对BL早期声门型喉癌进行光血管溶解切除似乎与KTP激光一样安全有效，并具有出色的语音结果。随着时间的推移，将需要额外的研究来评估BL患者的长期结果。
方法：3喉镜，2024.
