PDF(Pubmed)
Abstract：
UNASSIGNED: Most functional magnetic resonance research has primarily examined alterations in the affected kidney, often neglecting the contralateral kidney. Our study aims to investigate whether imaging parameters accurately depict changes in both the renal cortex and medulla in a unilateral ureteral obstruction rat model, thereby showcasing the utility of intravoxel incoherent motion (IVIM) in evaluating contralateral renal changes.
UNASSIGNED: Six rats underwent MR scans and were subsequently sacrificed for baseline histological examination. Following the induction of left ureteral obstruction, 48 rats were scanned, and the histopathological examinations were conducted on days 3, 7, 10, 14, 21, 28, 35, and 42. The apparent diffusion coefficient (ADC), pure molecular diffusion (D), pseudodiffusion (D*), and perfusion fraction (f) values were measured using IVIM.
UNASSIGNED: On the 10th day of obstruction, both cortical and medullary ADC values differed significantly between the UUO10 group and the sham group (p < 0.01). The cortical D values showed statistically significant differences between UUO3 group and sham group (p < 0.01) but not among UUO groups at other time point. Additionally, the cortical and medullary f values were statistically significant between the UUO21 group and the sham group (p < 0.01). Especially, the cortical f values exhibited significant differences between the UUO21 group and the UUO groups with shorter obstruction time (at time point of 3, 7, 10, 14 day) (p < 0.01).
UNASSIGNED: Significant hemodynamic alterations were observed in the contralateral kidney following renal obstruction. IVIM accurately captures changes in the unobstructed kidney. Particularly, the cortical f value exhibits the highest potential for assessing contralateral renal modifications.
UNASSIGNED: Six rats underwent MR scans and were subsequently sacrificed for baseline histological examination. Following the induction of left ureteral obstruction, 48 rats were scanned, and the histopathological examinations were conducted on days 3, 7, 10, 14, 21, 28, 35, and 42. The apparent diffusion coefficient (ADC), pure molecular diffusion (D), pseudodiffusion (D*), and perfusion fraction (f) values were measured using IVIM.
UNASSIGNED: On the 10th day of obstruction, both cortical and medullary ADC values differed significantly between the UUO10 group and the sham group (p < 0.01). The cortical D values showed statistically significant differences between UUO3 group and sham group (p < 0.01) but not among UUO groups at other time point. Additionally, the cortical and medullary f values were statistically significant between the UUO21 group and the sham group (p < 0.01). Especially, the cortical f values exhibited significant differences between the UUO21 group and the UUO groups with shorter obstruction time (at time point of 3, 7, 10, 14 day) (p < 0.01).
UNASSIGNED: Significant hemodynamic alterations were observed in the contralateral kidney following renal obstruction. IVIM accurately captures changes in the unobstructed kidney. Particularly, the cortical f value exhibits the highest potential for assessing contralateral renal modifications.
摘要：
■大多数功能磁共振研究主要检查了受影响的肾脏的改变，经常忽略对侧肾脏。我们的研究旨在探讨成像参数是否准确地描绘了单侧输尿管梗阻大鼠模型中肾皮质和髓质的变化。从而展示了体素内不相干运动（IVIM）在评估对侧肾脏变化中的实用性。
■六只大鼠进行MR扫描,随后处死用于基线组织学检查。在诱导左输尿管梗阻后，扫描48只大鼠,在第3、7、10、14、21、28、35和42天进行组织病理学检查。表观扩散系数(ADC)，纯分子扩散(D)，伪扩散（D*），和灌注分数(f)值使用IVIM测量。
■在阻塞的第10天，UUO10组与假手术组的皮质和髓质ADC值均有显著差异(p<0.01)。在其他时间点，UUO3组与假手术组之间的皮质D值显示出统计学上的显着差异（p<0.01），而在UUO组之间则没有统计学差异。此外,UUO21组与假手术组皮质和髓质f值差异有统计学意义(p<0.01)。尤其是,UUO21组和UUO组的皮质f值在阻塞时间较短(3、7、10、14天)时表现出显著差异(p<0.01)。
■在肾脏梗阻后的对侧肾脏中观察到明显的血液动力学改变。IVIM准确捕获通畅肾脏的变化。特别是,皮质f值显示出评估对侧肾脏修饰的最高潜力。
■六只大鼠进行MR扫描,随后处死用于基线组织学检查。在诱导左输尿管梗阻后，扫描48只大鼠,在第3、7、10、14、21、28、35和42天进行组织病理学检查。表观扩散系数(ADC)，纯分子扩散(D)，伪扩散（D*），和灌注分数(f)值使用IVIM测量。
■在阻塞的第10天，UUO10组与假手术组的皮质和髓质ADC值均有显著差异(p<0.01)。在其他时间点，UUO3组与假手术组之间的皮质D值显示出统计学上的显着差异（p<0.01），而在UUO组之间则没有统计学差异。此外,UUO21组与假手术组皮质和髓质f值差异有统计学意义(p<0.01)。尤其是,UUO21组和UUO组的皮质f值在阻塞时间较短(3、7、10、14天)时表现出显著差异(p<0.01)。
■在肾脏梗阻后的对侧肾脏中观察到明显的血液动力学改变。IVIM准确捕获通畅肾脏的变化。特别是,皮质f值显示出评估对侧肾脏修饰的最高潜力。
