PDF(Pubmed)
Abstract：
UNASSIGNED: Exploring factors associated with the outcome of patients with aneurysmal subarachnoid hemorrhage (aSAH) has become a hot focus in research. We sought to investigate the associations of inflammatory markers and blood cell count in cerebrospinal fluid with the outcome of aSAH patients.
UNASSIGNED: We carried a retrospective study including 200 patients with aSAH and surgeries. The associations of neutrophil, lymphocyte, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), systemic immune inflammation index (SII), system inflammation response index (SIRI), and blood cell count in cerebrospinal fluid on the 1st and 7th postoperative days with the outcome of aSAH patients were investigated by univariate analysis and multivariate logistic regression model.
UNASSIGNED: According to the modified Rankin scale (mRS) score, there were 147 patients with good outcome and 53 patients with poor outcome. The neutrophil, NLR, SIRI, and SII levels on the seventh postoperative day in patients with poor outcome were all significantly higher than patients with good outcome, P < 0.05. The multivariate logistic regression model including inflammatory markers and blood cell counts in cerebrospinal fluid on the 1st postoperative day confirmed that red blood cell count in cerebrospinal fluid (≥177 × 109/L; OR: 7.227, 95% CI: 1.160-45.050, P = 0.034) was possibly associated with poor outcome of aSAH patients, surgical duration (≥169 min), Fisher grade (III-IV), hypertension, and infections were also possibly associated with the poor outcome. The model including inflammatory markers and blood cell counts in cerebrospinal fluid on the 7th postoperative day confirmed that red blood cell count in cerebrospinal fluid (≥54 × 109/L; OR: 39.787, 95% CI: 6.799-232.836, P < 0.001) and neutrophil-lymphocyte ratio (≥8.16; OR: 6.362, 95% CI: 1.424-28.428, P = 0.015) were all possibly associated with poor outcome of aSAH patients. The NLR (r = 0.297, P = 0.007) and SIRI (r = 0.325, P = 0.003) levels were all correlated with the count of red blood cells in cerebrospinal fluid.
UNASSIGNED: Higher neutrophil-lymphocyte ratio and higher red blood cell count in cerebrospinal fluid were all possibly associated with poor outcome of patients with aneurysmal subarachnoid hemorrhage. However, we need a larger sample study.
UNASSIGNED: We carried a retrospective study including 200 patients with aSAH and surgeries. The associations of neutrophil, lymphocyte, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), systemic immune inflammation index (SII), system inflammation response index (SIRI), and blood cell count in cerebrospinal fluid on the 1st and 7th postoperative days with the outcome of aSAH patients were investigated by univariate analysis and multivariate logistic regression model.
UNASSIGNED: According to the modified Rankin scale (mRS) score, there were 147 patients with good outcome and 53 patients with poor outcome. The neutrophil, NLR, SIRI, and SII levels on the seventh postoperative day in patients with poor outcome were all significantly higher than patients with good outcome, P < 0.05. The multivariate logistic regression model including inflammatory markers and blood cell counts in cerebrospinal fluid on the 1st postoperative day confirmed that red blood cell count in cerebrospinal fluid (≥177 × 109/L; OR: 7.227, 95% CI: 1.160-45.050, P = 0.034) was possibly associated with poor outcome of aSAH patients, surgical duration (≥169 min), Fisher grade (III-IV), hypertension, and infections were also possibly associated with the poor outcome. The model including inflammatory markers and blood cell counts in cerebrospinal fluid on the 7th postoperative day confirmed that red blood cell count in cerebrospinal fluid (≥54 × 109/L; OR: 39.787, 95% CI: 6.799-232.836, P < 0.001) and neutrophil-lymphocyte ratio (≥8.16; OR: 6.362, 95% CI: 1.424-28.428, P = 0.015) were all possibly associated with poor outcome of aSAH patients. The NLR (r = 0.297, P = 0.007) and SIRI (r = 0.325, P = 0.003) levels were all correlated with the count of red blood cells in cerebrospinal fluid.
UNASSIGNED: Higher neutrophil-lymphocyte ratio and higher red blood cell count in cerebrospinal fluid were all possibly associated with poor outcome of patients with aneurysmal subarachnoid hemorrhage. However, we need a larger sample study.
摘要：
■探索与动脉瘤性蛛网膜下腔出血（aSAH）患者预后相关的因素已成为研究热点。我们试图研究脑脊液中炎症标志物和血细胞计数与aSAH患者预后的关系。
■我们进行了一项回顾性研究，包括200例aSAH和手术患者。中性粒细胞的关联，淋巴细胞，中性粒细胞-淋巴细胞比率（NLR），血小板-淋巴细胞比率（PLR），全身免疫炎症指数（SII），系统炎症反应指数（SIRI），采用单因素分析和多因素logistic回归模型对aSAH患者术后第1天和第7天脑脊液中血细胞计数与预后的关系进行研究。
■根据改良的Rankin量表（mRS）评分，其中147例患者预后良好,53例患者预后不良.中性粒细胞,NLR,SIRI,结果差的患者在术后第七天的SII水平均明显高于结果好的患者，P<0.05。术后第1天脑脊液中的炎性标志物和血细胞计数的多因素logistic回归模型证实，脑脊液中的红细胞计数（≥177×109/L；OR：7.227，95％CI：1.160-45.050，P=0.034）可能与aSAH患者的不良预后有关。手术时间（≥169分钟），费舍尔等级（III-IV），高血压,感染也可能与不良结局相关。在术后第7天，包括炎症标志物和脑脊液中的血细胞计数的模型证实，脑脊液中的红细胞计数（≥54×109/L；OR：39.787，95％CI：6.799-232.836，P<0.001）和中性粒细胞-淋巴细胞比率（≥8.16；OR：6.362，95％CI：1.424-28.428，P=0.015）均可能与SAH患者的不良预后有关。NLR(r=0.297,P=0.007)和SIRI(r=0.325,P=0.003)水平均与脑脊液红细胞计数相关。
■较高的中性粒细胞-淋巴细胞比率和较高的脑脊液红细胞计数都可能与动脉瘤性蛛网膜下腔出血患者的不良预后有关。然而,我们需要一个更大的样本研究。
■我们进行了一项回顾性研究，包括200例aSAH和手术患者。中性粒细胞的关联，淋巴细胞，中性粒细胞-淋巴细胞比率（NLR），血小板-淋巴细胞比率（PLR），全身免疫炎症指数（SII），系统炎症反应指数（SIRI），采用单因素分析和多因素logistic回归模型对aSAH患者术后第1天和第7天脑脊液中血细胞计数与预后的关系进行研究。
■根据改良的Rankin量表（mRS）评分，其中147例患者预后良好,53例患者预后不良.中性粒细胞,NLR,SIRI,结果差的患者在术后第七天的SII水平均明显高于结果好的患者，P<0.05。术后第1天脑脊液中的炎性标志物和血细胞计数的多因素logistic回归模型证实，脑脊液中的红细胞计数（≥177×109/L；OR：7.227，95％CI：1.160-45.050，P=0.034）可能与aSAH患者的不良预后有关。手术时间（≥169分钟），费舍尔等级（III-IV），高血压,感染也可能与不良结局相关。在术后第7天，包括炎症标志物和脑脊液中的血细胞计数的模型证实，脑脊液中的红细胞计数（≥54×109/L；OR：39.787，95％CI：6.799-232.836，P<0.001）和中性粒细胞-淋巴细胞比率（≥8.16；OR：6.362，95％CI：1.424-28.428，P=0.015）均可能与SAH患者的不良预后有关。NLR(r=0.297,P=0.007)和SIRI(r=0.325,P=0.003)水平均与脑脊液红细胞计数相关。
■较高的中性粒细胞-淋巴细胞比率和较高的脑脊液红细胞计数都可能与动脉瘤性蛛网膜下腔出血患者的不良预后有关。然而,我们需要一个更大的样本研究。
