UNASSIGNED: The National Health and Nutrition Examination Survey (NHANES) was the data source utilized in this study, spanning from 1999 to 2018. The study encompassed 2,500 RA participants in total. The dietary inflammatory potential was calculated by the dietary inflammation index (DII) score based on dietary recall interviews. The generalized multiple linear regression analyses were used to evaluate the relationship between DII and immune-inflammatory markers. Furthermore, subgroup analyses and restricted cubic spline models were performed.
UNASSIGNED: After full adjustments, there were significant positive correlations between DII levels and SII/NLR in RA patients (SII, β: 14.82, 95% CI: 5.14-24.50, p = 0.003; NLR, β: 0.04, 95% CI: 0.01-0.08, p = 0.005). It was noteworthy that inconsistent results were observed in the association between DII and SII as well as NLR in subgroups of red blood cell levels (Interaction p-value <0.001).
UNASSIGNED: Pro-inflammatory dietary status in the RA population is significantly positively correlated with SII and NLR, influenced by variations in red blood cell levels.
■国家健康和营养调查(NHANES)是本研究中使用的数据源,从1999年到2018年。该研究总共包括2500名RA参与者。通过基于饮食回忆访谈的饮食炎症指数(DII)评分计算饮食炎症潜能。使用广义多元线性回归分析来评估DII与免疫炎症标志物之间的关系。此外,我们进行了亚组分析和限制性三次样条模型.
■经过全面调整,RA患者的DII水平与SII/NLR之间存在显着正相关(SII,β:14.82,95%CI:5.14-24.50,p=0.003;NLR,β:0.04,95%CI:0.01-0.08,p=0.005)。值得注意的是,在红细胞水平的亚组中,在DII和SII以及NLR之间的关联中观察到不一致的结果(相互作用p值<0.001)。
■RA人群的促炎饮食状态与SII和NLR呈显著正相关,受红细胞水平变化的影响。