PDF(Pubmed)
Abstract：
Urachal carcinoma is an uncommon malignancy with a peculiar biomolecular characterization and therefore a complex approach. It was incorporated by the World Health Organization in 2004 in the tumors of the urinary system classification. This neoplasm is generally diagnosed in advanced stages. The standard treatment is surgical, however, due to the rarity and relatively late clinical manifestation of urachal carcinomas, the survival data are mostly case reports, as well as information about medical-surgical treatment based on evidence. The data used were extracted from both the physical and electronic clinical records. Among atypical presentations reported in the literature, we report a case of urachal adenocarcinoma with simultaneous glomerulonephritis as a paraneoplastic syndrome of which there is no report to date. Surgery was carried out in our patient, unfortunately with lifetime morbidity from kidney function replacement secondary to kidney function damage by glomerulonephritis, despite previous immunosuppression treatment for rapidly progressive glomerulonephritis. It is worth mentioning that if the initial diagnosis represents a clinical challenge, treatment is even more complex, given the little information that currently exists about it. Urachal carcinoma is a diagnostic and treatment challenge. Up to now, surgery has been the treatment of choice in localized or locally advanced disease, however, with a high morbidity for the patient.
摘要：
Urachal癌是一种罕见的恶性肿瘤，具有独特的生物分子特征，因此方法复杂。2004年被世界卫生组织纳入泌尿系肿瘤分类。这种肿瘤通常在晚期诊断。标准的治疗方法是手术,然而,由于脐管癌的罕见和相对较晚的临床表现，生存数据主要是病例报告，以及基于证据的医疗手术治疗信息。使用的数据是从物理和电子临床记录中提取的。在文献中报道的非典型陈述中，我们报道了一例脐尿管腺癌同时伴有肾小球肾炎的副肿瘤综合征，目前尚无报道。手术是在我们的病人身上进行的，不幸的是，由于肾小球肾炎继发于肾功能损害的肾功能替代，尽管以前曾对快速进展性肾小球肾炎进行免疫抑制治疗。值得一提的是，如果初始诊断代表临床挑战，治疗更加复杂,鉴于目前存在的关于它的信息很少。Urachal癌是诊断和治疗的挑战。到目前为止,手术一直是局部或局部晚期疾病的首选治疗方法，然而,对病人有很高的发病率。
