PDF(Pubmed)
Abstract：
UNASSIGNED: Elevated serum gamma-glutamyltranspeptidase (GGT) is an independent marker of the activation of systemic inflammation, while conditions associated with elevated triglyceride (TG) levels, such as type 2 diabetes, non-alcoholic fatty liver disease, obesity, and metabolic syndrome, are associated with an increased inflammatory burden. Moreover, serum liver enzymes (GGT, alanine aminotransferase [ALT], aspartate aminotransferase [AST], and alkaline phosphatase [ALP]) are associated with metabolic syndrome and its components, including hypertriglyceridemia. However, the relationship between liver enzymes and postprandial hypertriglyceridemia (PHTG) remains unclear. Therefore, in this study we conducted oral fat tolerance tests (OFTTs) to understand the differences in serum liver enzyme levels among individuals with different lipid tolerance levels and their correlation with PHTG.
UNASSIGNED: For the OFTT, we enrolled 202 non-diabetic volunteers whose fasting triglyceride (TG) levels were less than 1.7 mmol/L in this case-control study. The participants were categorized into two groups according to the TG levels at the 0- and 4-h OFTT: a postprandial normal TG (PNTG) group and a PHTG group. Routine fasting serum biochemical indices, liver enzyme (GGT, ALT, AST, and ALP) levels, and 0- and 4-h OFTT lipid levels were assessed.
UNASSIGNED: The PHTG group had significantly higher serum GGT and ALT levels and a lower AST/ALT ratio than those in the PNTG group. However, no significant difference was observed in AST and ALP levels compared with the PNTG group. After adjusting for major confounders, logistic regression analysis indicated a significant correlation between serum GGT and PHTG (odds ratio = 1.168, P < 0.001), but not with ALT level, AST level, AST/ALT ratio, and ALP level. The receiver operating characteristic curve analysis demonstrated that the serum GGT level was an effective predictor of PHTG.
UNASSIGNED: Serum GGT levels are significantly associated with PHTG risk and serve as an effective biomarker for early identification.
UNASSIGNED: For the OFTT, we enrolled 202 non-diabetic volunteers whose fasting triglyceride (TG) levels were less than 1.7 mmol/L in this case-control study. The participants were categorized into two groups according to the TG levels at the 0- and 4-h OFTT: a postprandial normal TG (PNTG) group and a PHTG group. Routine fasting serum biochemical indices, liver enzyme (GGT, ALT, AST, and ALP) levels, and 0- and 4-h OFTT lipid levels were assessed.
UNASSIGNED: The PHTG group had significantly higher serum GGT and ALT levels and a lower AST/ALT ratio than those in the PNTG group. However, no significant difference was observed in AST and ALP levels compared with the PNTG group. After adjusting for major confounders, logistic regression analysis indicated a significant correlation between serum GGT and PHTG (odds ratio = 1.168, P < 0.001), but not with ALT level, AST level, AST/ALT ratio, and ALP level. The receiver operating characteristic curve analysis demonstrated that the serum GGT level was an effective predictor of PHTG.
UNASSIGNED: Serum GGT levels are significantly associated with PHTG risk and serve as an effective biomarker for early identification.
摘要：
■血清γ-谷氨酰转肽酶（GGT）升高是全身性炎症激活的独立标志物，而与甘油三酯（TG）水平升高相关的条件，比如2型糖尿病，非酒精性脂肪性肝病,肥胖，代谢综合征,与炎症负担增加有关。此外，血清肝酶（GGT，丙氨酸转氨酶[ALT]，天冬氨酸转氨酶[AST]，和碱性磷酸酶[ALP]）与代谢综合征及其成分有关，包括高甘油三酯血症.然而,肝酶与餐后高甘油三酯血症(PHTG)之间的关系尚不清楚.因此,在这项研究中，我们进行了口服脂肪耐受试验（OFTT），以了解不同脂质耐受水平的个体之间血清肝酶水平的差异及其与PHTG的相关性。
■对于OFTT，在本病例对照研究中,我们纳入了空腹甘油三酯(TG)水平低于1.7mmol/L的202名非糖尿病志愿者.根据0和4小时OFTT的TG水平将参与者分为两组：餐后正常TG（PNTG）组和PHTG组。常规空腹血清生化指标,肝酶（GGT，ALT,AST,和ALP）水平，评估0-和4-hOFTT脂质水平。
■与PNTG组相比，PHTG组的血清GGT和ALT水平显着升高，AST/ALT比值降低。然而,与PNTG组相比，AST和ALP水平无显着差异。在调整了主要混杂因素后，Logistic回归分析显示血清GGT与PHTG之间存在显著相关性(比值比=1.168,P<0.001),但不是ALT水平，AST电平,AST/ALT比值,ALP水平。受试者工作特征曲线分析表明，血清GGT水平是PHTG的有效预测因子。
■血清GGT水平与PHTG风险显着相关，并可作为早期识别的有效生物标志物。
■对于OFTT，在本病例对照研究中,我们纳入了空腹甘油三酯(TG)水平低于1.7mmol/L的202名非糖尿病志愿者.根据0和4小时OFTT的TG水平将参与者分为两组：餐后正常TG（PNTG）组和PHTG组。常规空腹血清生化指标,肝酶（GGT，ALT,AST,和ALP）水平，评估0-和4-hOFTT脂质水平。
■与PNTG组相比，PHTG组的血清GGT和ALT水平显着升高，AST/ALT比值降低。然而,与PNTG组相比，AST和ALP水平无显着差异。在调整了主要混杂因素后，Logistic回归分析显示血清GGT与PHTG之间存在显著相关性(比值比=1.168,P<0.001),但不是ALT水平，AST电平,AST/ALT比值,ALP水平。受试者工作特征曲线分析表明，血清GGT水平是PHTG的有效预测因子。
■血清GGT水平与PHTG风险显着相关，并可作为早期识别的有效生物标志物。
