PDF(Pubmed)
Abstract：
UNASSIGNED: Osteoimmunology recognizes the relationship between bone cells and immune cells. Chronic osteoimmune dysregulation is present in bone marrow defects of the jaw (BMDJ) as fatty-degenerative osteonecrosis (FDOJ). In comparison to samples from healthy jaw bone, the cytokine analysis of samples of BMDJ/FDOJ from 128 patients showed downregulated TNF-α and IL-6 expression and the singular overexpression of the chemokine RANTES/CCL5.
UNASSIGNED: This paper raises the question of whether the osteoimmune defects due to incomplete wound healing in BMDJ/FDOJ in 128 patients are related to dysregulation of the Th1/Th2 ratio and regulatory T cell (T-reg) expression in a control group of 197 BMDJ/FDOJ patients, each presenting with BMDJ/FJOD and one of seven different immune disorders.
UNASSIGNED: In the control group, serum concentrations of the cytokines IFN-y and IL-4 were determined after stimulated cytokine release and displayed as Th1/Th2 ratios.
UNASSIGNED: Data show a shift in Th2 in more than 80% (n = 167) of the control cohort of 197 chronically ill patients with concomitant BMDJ/FDOJ. In these 167 subjects, the Th1/Th2 ratio was <6.1 demonstrating impaired immune regulation. Forty-seven subjects or 30% showed not only a shift in Th2 but also excessive T-reg overactivation with levels of >1.900 pg/mL, indicating strongly downregulated immune activity.
UNASSIGNED: BMDJ/FDOJ is characterized by a lack of Th1 cytokines and an excessive expression of RANTES/CCL5 and IL-1ra and, thus, the inversion of an acute inflammatory cytokine pattern. In contrast, abdominal fat contains a very high proportion of regulatory Th1 cells and produces an inflammatory immune response through the high overexpression of TNF-α and IL-6. The lack of Th1 activation in BMDJ/FDOJ areas inhibits normal wound healing and supports the persistence of BMDJ/FDOJ.
UNASSIGNED: The Th1/Th2 ratio requires greater consideration, especially with respect to wound healing following dental surgical interventions, such as jaw surgery, implantation and augmentation, to avoid the emergence of the osteoimmune situation that is characteristic of BMDJ/FDOJ.
UNASSIGNED: This paper raises the question of whether the osteoimmune defects due to incomplete wound healing in BMDJ/FDOJ in 128 patients are related to dysregulation of the Th1/Th2 ratio and regulatory T cell (T-reg) expression in a control group of 197 BMDJ/FDOJ patients, each presenting with BMDJ/FJOD and one of seven different immune disorders.
UNASSIGNED: In the control group, serum concentrations of the cytokines IFN-y and IL-4 were determined after stimulated cytokine release and displayed as Th1/Th2 ratios.
UNASSIGNED: Data show a shift in Th2 in more than 80% (n = 167) of the control cohort of 197 chronically ill patients with concomitant BMDJ/FDOJ. In these 167 subjects, the Th1/Th2 ratio was <6.1 demonstrating impaired immune regulation. Forty-seven subjects or 30% showed not only a shift in Th2 but also excessive T-reg overactivation with levels of >1.900 pg/mL, indicating strongly downregulated immune activity.
UNASSIGNED: BMDJ/FDOJ is characterized by a lack of Th1 cytokines and an excessive expression of RANTES/CCL5 and IL-1ra and, thus, the inversion of an acute inflammatory cytokine pattern. In contrast, abdominal fat contains a very high proportion of regulatory Th1 cells and produces an inflammatory immune response through the high overexpression of TNF-α and IL-6. The lack of Th1 activation in BMDJ/FDOJ areas inhibits normal wound healing and supports the persistence of BMDJ/FDOJ.
UNASSIGNED: The Th1/Th2 ratio requires greater consideration, especially with respect to wound healing following dental surgical interventions, such as jaw surgery, implantation and augmentation, to avoid the emergence of the osteoimmune situation that is characteristic of BMDJ/FDOJ.
摘要：
■骨免疫学识别骨细胞和免疫细胞之间的关系。慢性骨免疫失调作为脂肪变性骨坏死（FDOJ）存在于颌骨的骨髓缺损（BMDJ）中。与健康颌骨的样本相比，对来自128例患者的BMDJ/FDOJ样本的细胞因子分析显示,TNF-α和IL-6表达下调,趋化因子RANTES/CCL5单一过表达.
■本文提出了一个问题，即128例BMDJ/FDOJ患者伤口愈合不完全导致的骨免疫缺陷是否与197例BMDJ/FDOJ患者对照组的Th1/Th2比率和调节性T细胞（T-reg）表达失调有关，每种都有BMDJ/FJOD和七种不同的免疫疾病之一。
■在对照组中，细胞因子IFN-Y和IL-4的血清浓度在刺激细胞因子释放后测定并显示为Th1/Th2比率。
■数据显示，在197例合并BMDJ/FDOJ的慢性病患者的对照组中，超过80％（n=167）的Th2发生了变化。在这167个科目中，Th1/Th2比值<6.1，表明免疫调节受损。47名受试者或30％的受试者不仅显示Th2的变化，而且过度的T-reg过度激活，水平>1.900pg/mL，表明强烈下调的免疫活性。
■BMDJ/FDOJ的特征是缺乏Th1细胞因子和RANTES/CCL5和IL-1ra的过度表达，因此，急性炎症细胞因子模式的反转。相比之下,腹部脂肪含有非常高比例的调节性Th1细胞，并通过TNF-α和IL-6的高表达产生炎症免疫应答。BMDJ/FDOJ区域中Th1活化的缺乏抑制正常伤口愈合并支持BMDJ/FDOJ的持续存在。
■Th1/Th2比率需要更多考虑，特别是在牙科手术干预后的伤口愈合方面，比如下颌手术，植入和增强，避免BMDJ/FDOJ特有的骨免疫情况的出现。
■本文提出了一个问题，即128例BMDJ/FDOJ患者伤口愈合不完全导致的骨免疫缺陷是否与197例BMDJ/FDOJ患者对照组的Th1/Th2比率和调节性T细胞（T-reg）表达失调有关，每种都有BMDJ/FJOD和七种不同的免疫疾病之一。
■在对照组中，细胞因子IFN-Y和IL-4的血清浓度在刺激细胞因子释放后测定并显示为Th1/Th2比率。
■数据显示，在197例合并BMDJ/FDOJ的慢性病患者的对照组中，超过80％（n=167）的Th2发生了变化。在这167个科目中，Th1/Th2比值<6.1，表明免疫调节受损。47名受试者或30％的受试者不仅显示Th2的变化，而且过度的T-reg过度激活，水平>1.900pg/mL，表明强烈下调的免疫活性。
■BMDJ/FDOJ的特征是缺乏Th1细胞因子和RANTES/CCL5和IL-1ra的过度表达，因此，急性炎症细胞因子模式的反转。相比之下,腹部脂肪含有非常高比例的调节性Th1细胞，并通过TNF-α和IL-6的高表达产生炎症免疫应答。BMDJ/FDOJ区域中Th1活化的缺乏抑制正常伤口愈合并支持BMDJ/FDOJ的持续存在。
■Th1/Th2比率需要更多考虑，特别是在牙科手术干预后的伤口愈合方面，比如下颌手术，植入和增强，避免BMDJ/FDOJ特有的骨免疫情况的出现。
