PDF(Pubmed)
Abstract：
Sweet syndrome is an uncommon inflammatory disorder characterized by the abrupt appearance of painful, erythematous papules, plaques, or nodules on the skin. Fever and leukocytosis frequently accompany the cutaneous lesions. In addition, involvement of the eyes, musculoskeletal system, and internal organs may occur. Sweet syndrome has been associated with a broad range of disorders. There are three subtypes: classical Sweet syndrome, malignancy-associated Sweet syndrome, and drug-induced Sweet syndrome. Classical Sweet syndrome is not associated with malignancy or drugs. It is essentially associated with an upper respiratory infection, gastrointestinal infection, inflammatory bowel disease, and pregnancy. Malignancy-associated Sweet syndrome is associated with hematologic malignancy more than solid malignancy, most commonly with acute myeloid leukemia. Drug-induced Sweet syndrome usually develops approximately two weeks after drug exposure, in patients who lack a prior history of exposure to the inciting drug. Here we are discussing our patient, a 68-year-old male who presented eight weeks after starting chemotherapy with pemetrexed, carboplatin, and pembrolizumab for left lung adenocarcinoma with macular rash. On further investigation with biopsy was found to have neutrophilic dermatitis, hence being diagnosed with drug-induced Sweet syndrome. Histopathology revealed a dermis with infiltration of neutrophils with lekocytoclasia.
摘要：
Sweet综合征是一种罕见的炎症性疾病，其特征是突然出现疼痛，红斑丘疹，斑块,或者皮肤上的结节.发热和白细胞增多常伴随皮肤病变。此外,眼睛的参与，肌肉骨骼系统,和内部器官可能发生。Sweet综合征与广泛的疾病有关。有三种亚型：经典的Sweet综合征，恶性肿瘤相关的Sweet综合征，和药物诱发的Sweet综合征.经典的Sweet综合征与恶性肿瘤或药物无关。它基本上与上呼吸道感染有关，胃肠道感染,炎症性肠病，和怀孕。恶性相关的Sweet综合征与血液系统恶性肿瘤的相关性大于实体恶性肿瘤，最常见的是急性髓细胞性白血病。药物诱发的Sweet综合征通常在药物暴露后大约两周出现，在没有接触过煽动性药物史的患者中。我们在讨论我们的病人,一名68岁男性在开始培美曲塞化疗8周后出现，卡铂,和派博利珠单抗治疗左肺腺癌伴黄斑皮疹。经进一步活检发现有嗜中性粒细胞性皮炎，因此被诊断为药物诱导的Sweet综合征。组织病理学显示真皮有嗜中性粒细胞浸润并伴有红细胞增多症。
