PDF(Pubmed)
Abstract：
UNASSIGNED: This study aims to analyze the clinical features of Kawasaki disease (KD) shock syndrome (KDSS) and explore its early predictors.
UNASSIGNED: A retrospective case-control study was used to analyze KD cases from February 2016 to October 2023 in our hospital. A total of 28 children with KDSS and 307 children who did not develop KDSS were included according to matching factors. Baseline information, clinical manifestations, and laboratory indicators were compared between the two groups. Indicators of differences were analyzed based on univariate analysis; binary logistic regression analysis was used to identify the risk factors for KDSS, and then receiver operating characteristic analysis was performed to establish a predictive score model for KDSS.
UNASSIGNED: Elevated neutrophil-to-lymphocyte ratio(NLR) and decreased fibrinogen (FIB) and Na were independent risk factors for KDSS; the scoring of the above risk factors according to the odds ratio value eventually led to the establishment of a new scoring system: NLR ≥ 7.99 (6 points), FIB ≤ 5.415 g/L (1 point), Na ≤ 133.05 mmol/L (3 points), and a total score of ≥3.5 points were high-risk factors for progression to KDSS; otherwise, they were considered to be low-risk factors.
UNASSIGNED: Children with KD with NLR ≥ 7.99, FIB ≤ 5.415 g/L, and Na ≤ 133.05 mmol/L, and those with two or more of the above risk factors, are more likely to progress to KDSS, which helps in early clinical diagnosis and treatment.
UNASSIGNED: A retrospective case-control study was used to analyze KD cases from February 2016 to October 2023 in our hospital. A total of 28 children with KDSS and 307 children who did not develop KDSS were included according to matching factors. Baseline information, clinical manifestations, and laboratory indicators were compared between the two groups. Indicators of differences were analyzed based on univariate analysis; binary logistic regression analysis was used to identify the risk factors for KDSS, and then receiver operating characteristic analysis was performed to establish a predictive score model for KDSS.
UNASSIGNED: Elevated neutrophil-to-lymphocyte ratio(NLR) and decreased fibrinogen (FIB) and Na were independent risk factors for KDSS; the scoring of the above risk factors according to the odds ratio value eventually led to the establishment of a new scoring system: NLR ≥ 7.99 (6 points), FIB ≤ 5.415 g/L (1 point), Na ≤ 133.05 mmol/L (3 points), and a total score of ≥3.5 points were high-risk factors for progression to KDSS; otherwise, they were considered to be low-risk factors.
UNASSIGNED: Children with KD with NLR ≥ 7.99, FIB ≤ 5.415 g/L, and Na ≤ 133.05 mmol/L, and those with two or more of the above risk factors, are more likely to progress to KDSS, which helps in early clinical diagnosis and treatment.
摘要：
■本研究旨在分析川崎病（KD）休克综合征（KDSS）的临床特征，并探讨其早期预测因子。
■回顾性病例对照研究用于分析我院2016年2月至2023年10月的KD病例。根据匹配因素，共纳入28例KDSS儿童和307例未发展KDSS儿童。基线信息，临床表现，比较两组的实验室指标。单因素分析差异指标;采用二元logistic回归分析确定KDSS的危险因素,然后进行受试者工作特性分析，建立KDSS的预测得分模型。
■中性粒细胞与淋巴细胞比值（NLR）升高、纤维蛋白原（FIB）和Na降低是KDSS的独立危险因素；上述危险因素根据比值比值进行评分，最终建立了新的评分系统：NLR≥7.99（6分），FIB≤5.415g/L(1分),Na≤133.05mmol/L(3分),总分≥3.5分是进展为KDSS的高危因素；否则，它们被认为是低风险因素.
■NLR≥7.99，FIB≤5.415g/L的KD儿童，Na≤133.05mmol/L，以及那些有两个或更多上述危险因素的人，更有可能发展到KDSS，这有助于早期临床诊断和治疗。
■回顾性病例对照研究用于分析我院2016年2月至2023年10月的KD病例。根据匹配因素，共纳入28例KDSS儿童和307例未发展KDSS儿童。基线信息，临床表现，比较两组的实验室指标。单因素分析差异指标;采用二元logistic回归分析确定KDSS的危险因素,然后进行受试者工作特性分析，建立KDSS的预测得分模型。
■中性粒细胞与淋巴细胞比值（NLR）升高、纤维蛋白原（FIB）和Na降低是KDSS的独立危险因素；上述危险因素根据比值比值进行评分，最终建立了新的评分系统：NLR≥7.99（6分），FIB≤5.415g/L(1分),Na≤133.05mmol/L(3分),总分≥3.5分是进展为KDSS的高危因素；否则，它们被认为是低风险因素.
■NLR≥7.99，FIB≤5.415g/L的KD儿童，Na≤133.05mmol/L，以及那些有两个或更多上述危险因素的人，更有可能发展到KDSS，这有助于早期临床诊断和治疗。
