PDF(Pubmed)
Abstract：
Female-specific reproductive factors and exogeneous estrogen use are associated with cognition in later life. However, the underlying mechanisms are not understood. The present study aimed to investigate the effect of reproductive factors on neuroimaging biomarkers of Alzheimer\'s disease (AD) and cerebrovascular pathologies.
We evaluated 389 females (median age of 71.7 years) enrolled in the Mayo Clinic Study of Aging with reproductive history data and longitudinal magnetic resonance imaging (MRI) scans. We used linear mixed effect models to examine the associations between reproductive factors and changes in neuroimaging measures.
Ever hormonal contraception (HC) use was longitudinally associated with higher fractional anisotropy across the corpus callosum, lower white matter hyperintensity (WMH) volume, and greater cortical thickness in an AD meta-region of interest (ROI). The initiation of menopausal hormone therapy (MHT) > 5 years post menopause was associated with higher WMH volume.
HC use and initiation of MHT >5 years post menopause were generally associated with neuroimaging biomarkers of cerebrovascular pathologies.
Hormonal contraception use was associated with better brain white matter (WM) integrity. Initiation of menopausal hormone therapy >5 years post menopause was associated with worsening brain WM integrity. Hormonal contraception use was associated with greater cortical thickness. Ages at menarche and menopause and number of pregnancies were not associated with imaging measures. There were few associations between reproductive factors or exogenous estrogens and amyloid or tau PET.
We evaluated 389 females (median age of 71.7 years) enrolled in the Mayo Clinic Study of Aging with reproductive history data and longitudinal magnetic resonance imaging (MRI) scans. We used linear mixed effect models to examine the associations between reproductive factors and changes in neuroimaging measures.
Ever hormonal contraception (HC) use was longitudinally associated with higher fractional anisotropy across the corpus callosum, lower white matter hyperintensity (WMH) volume, and greater cortical thickness in an AD meta-region of interest (ROI). The initiation of menopausal hormone therapy (MHT) > 5 years post menopause was associated with higher WMH volume.
HC use and initiation of MHT >5 years post menopause were generally associated with neuroimaging biomarkers of cerebrovascular pathologies.
Hormonal contraception use was associated with better brain white matter (WM) integrity. Initiation of menopausal hormone therapy >5 years post menopause was associated with worsening brain WM integrity. Hormonal contraception use was associated with greater cortical thickness. Ages at menarche and menopause and number of pregnancies were not associated with imaging measures. There were few associations between reproductive factors or exogenous estrogens and amyloid or tau PET.
摘要：
背景：女性特异性生殖因素和外源雌激素的使用与晚年的认知有关。然而,潜在的机制还不清楚。本研究旨在探讨生殖因素对阿尔茨海默病(AD)和脑血管病变神经影像学生物标志物的影响。
方法：我们评估了参与梅奥诊所衰老研究的389名女性（中位年龄为71.7岁），包括生殖史数据和纵向磁共振成像（MRI）扫描。我们使用线性混合效应模型来检查生殖因素与神经影像学测量变化之间的关联。
结果：经常使用激素避孕（HC）与整个call体的较高各向异性分数纵向相关，较低的白质高强度（WMH）体积，和更大的皮质厚度在AD元感兴趣区域（ROI）。绝经后>5年开始绝经激素治疗（MHT）与较高的WMH量相关。
结论：绝经5年后使用HC和启动MHT通常与脑血管病理的神经影像学生物标志物相关。
结论：使用激素避孕与更好的脑白质（WM）完整性相关。绝经后>5年开始绝经激素治疗与脑WM完整性恶化有关。激素避孕的使用与更大的皮质厚度相关。初潮和绝经年龄以及怀孕次数与影像学检查无关。生殖因素或外源性雌激素与淀粉样蛋白或tauPET之间几乎没有关联。
方法：我们评估了参与梅奥诊所衰老研究的389名女性（中位年龄为71.7岁），包括生殖史数据和纵向磁共振成像（MRI）扫描。我们使用线性混合效应模型来检查生殖因素与神经影像学测量变化之间的关联。
结果：经常使用激素避孕（HC）与整个call体的较高各向异性分数纵向相关，较低的白质高强度（WMH）体积，和更大的皮质厚度在AD元感兴趣区域（ROI）。绝经后>5年开始绝经激素治疗（MHT）与较高的WMH量相关。
结论：绝经5年后使用HC和启动MHT通常与脑血管病理的神经影像学生物标志物相关。
结论：使用激素避孕与更好的脑白质（WM）完整性相关。绝经后>5年开始绝经激素治疗与脑WM完整性恶化有关。激素避孕的使用与更大的皮质厚度相关。初潮和绝经年龄以及怀孕次数与影像学检查无关。生殖因素或外源性雌激素与淀粉样蛋白或tauPET之间几乎没有关联。
