Abstract：
Alternating electric fields (AEFs) at intermediate frequencies (100-300 kHz) and low intensities (1-3 V/cm) have shown promise as an effective approach for inhibiting cancer cell proliferation. However, a noticeable research gap exists in comparing the biophysical properties of invasive and non-invasive AEFs methods, and AEFs delivery strategies require further improvement. In this study, we constructed a realistic head model to simulate the effects of non-invasive and invasive AEFs on malignant gliomas. Additionally, a novel method was proposed involving the placement of a return electrode under the scalp. We simulated the electric field and temperature distributions in the brain tissue for each method. Our results underscore the advantages of invasive AEFs, showcasing their superior tumor-targeting abilities and reduced energy requirements. The analysis of brain tissue temperature changes reveals that non-invasive AEFs primarily generate heat at the scalp level, whereas invasive methods localize heat production within the tumor itself, thereby preserving surrounding healthy brain tissue. Our proposed invasive AEFs method also shows potential for selective electric field intervention. In conclusion, invasive AEFs demonstrate potential for precise and effective tumor treatment. Its enhanced targeting capabilities and limited impact on healthy tissue make it a promising avenue for further research in the realm of cancer treatment.
摘要：
中频（100-300kHz）和低强度（1-3V/cm）的交变电场（AEF）有望成为抑制癌细胞增殖的有效方法。然而,在比较侵入性和非侵入性AEF方法的生物物理特性方面存在明显的研究差距，和AEF交付策略需要进一步改进。在这项研究中,我们构建了一个真实的头部模型来模拟非侵入性和侵入性AEFs对恶性胶质瘤的影响。此外,提出了一种新的方法，涉及在头皮下放置返回电极。我们模拟了每种方法在脑组织中的电场和温度分布。我们的结果强调了侵入性AEF的优势，展示其卓越的肿瘤靶向能力和减少的能量需求。对脑组织温度变化的分析表明，非侵入性AEF主要在头皮水平产生热量，而侵入性方法将热量产生定位在肿瘤本身内，从而保护周围健康的脑组织。我们提出的侵入性AEFs方法也显示了选择性电场干预的潜力。总之,侵袭性AEFs显示出精确有效的肿瘤治疗潜力。其增强的靶向能力和对健康组织的有限影响使其成为癌症治疗领域进一步研究的有希望的途径。
