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Abstract：
To explore the clinicopathological characteristics and prognostic significance of casting-type calcification (CC) in patients with breast cancer presenting with microcalcification on mammography. Data on patients with invasive breast cancer who had mammographic calcification was retrospectively analyzed. The chi-square test was utilized to assess the clinicopathological characteristics of two forms of CC-related breast cancer. The examination of prognostic variables was conducted using Kaplan-Meier and Cox regression analyses. A total of 427 eligible patients were included in this study. Chi-square analysis indicated that the presence of CC was associated with estrogen receptor (ER) negativity (P = 0.005), progesterone receptor (PR) negativity (P < 0.001), and epidermal growth factor receptor 2 (HER-2) positivity (P < 0.001); among these, the association was stronger with the CC-predominant type. After a median follow-up of 82 months, those with CC had a worse 5-year recurrence-free survival (RFS) (77.1% vs. 86.9%, p = 0.036; hazard ratio [HR], 1.86; 95% confidence interval [CI] 1.04-3.31) and overall survival (OS) (84.0% vs. 94.4%, p = 0.007; HR, 2.99; 95% CI 1.34-6.65) rates. In COX regression analysis, such differences were still observed in HER-2 positive subgroups (RFS: HR: 2.45, 95% CI 1-5.97, P = 0.049; OS: HR: 4.53, 95% CI 1.17-17.52, P = 0.029). In patients with invasive breast cancer exhibiting calcifications on mammography, the presence of CC, especially the CC-predominant type, is linked to a higher frequency of hormone receptor negativity and HER-2 positivity. The presence of CC is associated with an unfavorable 5-year RFS and OS rates.
摘要：
探讨钼靶X线微钙化患者铸造型钙化(CC)的临床病理特征及预后意义。回顾性分析乳腺钙化的浸润性乳腺癌患者的数据。卡方检验用于评估两种形式的CC相关乳腺癌的临床病理特征。使用Kaplan-Meier和Cox回归分析对预后变量进行检查。共有427名符合条件的患者被纳入本研究。卡方分析表明，CC的存在与雌激素受体（ER）阴性有关（P=0.005）。孕激素受体（PR）阴性（P<0.001），和表皮生长因子受体2（HER-2）阳性（P<0.001）；其中，与CC占优势型的相关性更强。经过82个月的中位随访，CC患者的5年无复发生存率（RFS）较差（77.1％vs.86.9%,p=0.036；危险比[HR]，1.86；95%置信区间[CI]1.04-3.31）和总生存期（OS）（84.0%vs.94.4%,p=0.007;HR,2.99；95%CI1.34-6.65）率。在COX回归分析中，在HER-2阳性亚组中仍观察到这种差异(RFS:HR:2.45,95%CI1-5.97,P=0.049;OS:HR:4.53,95%CI1.17-17.52,P=0.029).浸润性乳腺癌患者在乳房X线照相术上显示钙化，CC的存在，尤其是CC型，与更高频率的激素受体阴性和HER-2阳性有关。CC的存在与不利的5年RFS和OS率有关。
