Abstract：
Modified biopolymers that are based on prebiotics have been found to significantly contribute to immunomodulatory events. In recent years, there has been a growing use of modified biomaterials and polymer-functionalized nanomaterials in the treatment of various tumors by activating immune cells. However, the effectiveness of immune cells against tumors is hindered by several biological barriers, which highlights the importance of harnessing prebiotic-based biopolymers to enhance host defenses against cancer, thus advancing cancer prevention strategies. Inulin, in particular, plays a crucial role in activating immune cells and promoting the secretion of cytokines. Therefore, this mini-review aims to emphasize the importance of inulin in immunomodulatory responses, the development of inulin-based hybrid biopolymers, and the role of inulin in enhancing immunity and modifying cell surfaces. Furthermore, we discuss the various approaches of chemical modification for inulin and their potential use in cancer treatment, particularly in the field of cancer immunotherapy.
摘要：
已经发现基于益生元的改性生物聚合物显著有助于免疫调节事件。近年来,改性生物材料和聚合物功能化纳米材料在通过激活免疫细胞治疗各种肿瘤中的应用越来越多。然而,免疫细胞对抗肿瘤的有效性受到几个生物障碍的阻碍，这突出了利用基于益生元的生物聚合物来增强宿主对癌症的防御能力的重要性，从而推进癌症预防策略。菊粉,特别是,在激活免疫细胞和促进细胞因子分泌中起着至关重要的作用。因此,这篇小型综述旨在强调菊粉在免疫调节反应中的重要性，菊粉基混合生物聚合物的发展，以及菊粉在增强免疫力和修饰细胞表面方面的作用。此外，我们讨论了菊粉的各种化学修饰方法及其在癌症治疗中的潜在用途，特别是在癌症免疫治疗领域。
