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Abstract：
This study aimed to assess the effect of intraocular pressure (IOP) changes on biometry and intraocular lens (IOL) power calculation in patients diagnosed with primary open-angle glaucoma (POAG) and ocular hypertension (OHT). This prospective non-randomized cohort study enrolled patients with diagnosed POAG and OHT, presenting with IOP levels exceeding 25 mmHg. Thai Clinical Trials Registry number was TCTR20180912007. Optical biometry, encompassing measurements such as corneal thickness (CCT), keratometry, anterior chamber depth (ACD), and axial length, was conducted before and after IOP reduction. The IOL power was also determined using the SRK/T formula. The main outcomes measured were alterations in biometry and IOL power. Correlations between IOP, biometric parameters, and IOL power were analyzed. In total, 28 eyes were included in the study, with a mean patient age of 65.71±10.2 years. After IOP reduction, all biometric parameters, except CCT and ACD, exhibited a decrease without reaching statistical significance (all p>0.05). Meanwhile, IOL power showed a slight increase of 0.214±0.42 diopters (P = 0.035). The correlation between IOP and biometric parameters was found to be weak. However, there was a moderate correlation between IOP and IOL power (r2 = 0.267). Notably, IOL power tended to increase by more than 0.5 diopters when IOP decreased by more than 10 mmHg (p < 0.001). In conclusion, changes in IOP among patients with POAG and OHT do not significantly impact biometry and IOL power calculations. Nonetheless, it may be prudent to consider a slight adjustment in IOL power when IOP is lowered by more than 10 mmHg.
摘要：
本研究旨在评估诊断为原发性开角型青光眼（POAG）和高眼压（OHT）的患者眼内压（IOP）变化对生物测量和人工晶状体（IOL）功率计算的影响。这项前瞻性非随机队列研究招募了诊断为POAG和OHT的患者，眼压水平超过25mmHg。泰国临床试验登记号为TCTR20180912007。光学生物测量,包括测量，如角膜厚度（CCT），角膜曲率测量,前房深度（ACD），和轴向长度，在降低IOP之前和之后进行。还使用SRK/T公式确定IOL功率。测量的主要结果是生物特征和IOL功率的改变。IOP之间的相关性，生物测定参数,并对IOL功率进行分析。总的来说,28只眼睛被纳入研究，患者平均年龄为65.71±10.2岁。降低IOP后,所有生物参数，除了CCT和ACD,表现出下降，但没有达到统计学意义(所有p>0.05)。同时,IOL屈光度略有增加，为0.214±0.42屈光度（P=0.035）。发现IOP与生物特征参数之间的相关性较弱。然而,IOP与IOL功率之间存在中度相关性（r2=0.267）。值得注意的是,当IOP降低超过10mmHg时,IOL功率倾向于增加超过0.5屈光度(p<0.001)。总之,POAG和OHT患者的IOP变化对生物测量和IOL功率计算没有显著影响.尽管如此，当IOP降低超过10mmHg时,考虑轻微调整IOL功率可能是谨慎的.
