Abstract：
Head and neck atopic dermatitis (HNAD) is a subtype of atopic dermatitis (AD), a common inflammatory skin condition with a distinctive clinical appearance. Malassezia spp., a predominant skin yeast, is considered to exacerbate HNAD. In this study, we investigate the prevalence of Malassezia-specific IgE among HNAD patients. A comprehensive search was performed for observational studies analysing the association between Malassezia-specific IgE and HNAD. This study was performed according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses 2020 checklist and quality was assessed via the Newcastle-Ottawa Quality Assessment Scale (NOS). Fourteen observational studies (840 patients) were included in the analysis. 58% of HNAD patients were male (95% CI: 45.2-69.7). Overall prevalence of Malassezia-specific IgE among HNAD patients was 79.3% (95% CI: 57.5-91.5). Prevalence of Malassezia-specific IgE among HNAD patients varied significantly between geographical regions (p = 0.0441), with 88% in non-Asian regions (95% CI: 61.06-97.17) and 54.73% in Asian regions (95% CI: 34.36-73.63). Malassezia-specific IgE prevalence among HNAD patients varied significantly among studies of higher and lower NOS quality score (p = 0.0386), with 95.42% in studies with NOS ≥7 (95% CI: 63.54-99.60) and 58.05% in studies with NOS <7 (95% CI: 41.44-73.01). Malassezia-specific IgE prevalence among HNAD patients did not vary significantly between more and less predominant Malassezia species (p = 0.1048). Malassezia spp. plays a crucial role in the pathogenesis of HNAD, and IgE anti-Malassezia antibodies appeared to be a common marker for HNAD. Understanding the pathophysiology of Malassezia in HNAD can help develop more targeted therapeutic approaches in managing AD.
摘要：
头颈部特应性皮炎（HNAD）是特应性皮炎（AD）的一种亚型，一种常见的炎症性皮肤病，具有独特的临床表现。马拉色菌。,一种主要的皮肤酵母，被认为加剧了HNAD。在这项研究中,我们调查了HNAD患者中马拉色菌特异性IgE的患病率.对分析马拉色菌特异性IgE和HNAD之间关联的观察性研究进行了全面搜索。本研究根据2020年系统评价和荟萃分析首选报告项目清单进行，并通过纽卡斯尔-渥太华质量评估量表（NOS）评估质量。14项观察性研究（840名患者）纳入分析。58％的HNAD患者为男性（95％CI：45.2-69.7）。HNAD患者中马拉色菌特异性IgE的总体患病率为79.3%(95%CI:57.5-91.5)。HNAD患者中Malassezia特异性IgE的患病率在地理区域之间存在显着差异（p=0.0441），88%在非亚洲地区（95%CI：61.06-97.17），54.73%在亚洲地区（95%CI：34.36-73.63）。在NOS质量评分较高和较低的研究中，HNAD患者的马拉色菌特异性IgE患病率差异显着（p=0.0386），在NOS≥7的研究中为95.42％（95％CI：63.54-99.60），在NOS<7的研究中为58.05％（95％CI：41.44-73.01）。HNAD患者中马拉色菌特异性IgE的患病率在更多和更少的主要马拉色菌物种之间没有显着差异（p=0.1048）。马拉色菌。在HNAD的发病机制中起着至关重要的作用,IgE抗马拉色菌抗体似乎是HNAD的常见标志物。了解HNAD中马拉色菌的病理生理学可以帮助开发更有针对性的治疗方法来管理AD。
