PDF(Pubmed)
Abstract：
The development of metallic joint prostheses has been ongoing for more than a century alongside advancements in hip and knee arthroplasty. Among the materials utilized, the Cobalt-Chromium-Molybdenum (Co-Cr-Mo) and Titanium-Aluminum-Vanadium (Ti-Al-V) alloys are predominant in joint prosthesis construction, predominantly due to their commendable biocompatibility, mechanical strength, and corrosion resistance. Nonetheless, over time, the physical wear, electrochemical corrosion, and inflammation induced by these alloys that occur post-implantation can cause the release of various metallic components. The released metals can then flow and metabolize in vivo, subsequently causing potential local or systemic harm. This review first details joint prosthesis development and acknowledges the release of prosthetic metals. Second, we outline the metallic concentration, biodistribution, and elimination pathways of the released prosthetic metals. Lastly, we discuss the possible organ, cellular, critical biomolecules, and significant signaling pathway toxicities and adverse effects that arise from exposure to these metals.
摘要：
随着髋关节和膝关节置换术的发展，金属关节假体的发展已经持续了一个多世纪。在使用的材料中，钴-铬-钼（Co-Cr-Mo）和钛-铝-钒（Ti-Al-V）合金在关节假体结构中占主导地位，主要是由于它们值得称赞的生物相容性，机械强度,和耐腐蚀性。尽管如此，随着时间的推移,身体的磨损，电化学腐蚀，植入后由这些合金引起的炎症可导致各种金属成分的释放。释放的金属可以在体内流动和代谢，随后造成潜在的局部或系统性伤害。这篇评论首先详细介绍了关节假体的开发，并承认了假体金属的释放。第二,我们概述了金属的浓度，生物分布，以及释放的假体金属的消除途径。最后,我们讨论可能的器官，细胞，关键生物分子，以及暴露于这些金属引起的显着信号通路毒性和不利影响。
