PDF(Pubmed)
Abstract：
UNASSIGNED: We aimed to study trabecular bone score (TBS) association with disease parameters and vertebral fractures (VFs) in patients with axial spondyloarthritis.
UNASSIGNED: Patients diagnosed with axial spondyloarthritis were included in this cross-sectional study. Dual-energy X-ray absorptiometry was used to measure BMD in the lumbar spine and TBS. Low TBS was defined as ≤1.31. The association between TBS and disease parameters including Ankylosing Spondylitis Disease Activity Score (ASDAS), BASDAI, BASFI and BASMI was studied using logistic regressions.
UNASSIGNED: Our study included 56 patients, with a mean age of 38.9 ± 13.5 years and a mean disease duration of 12.7 ± 7.7 years. Patients with low TBS were significantly older and had higher waist circumference and body mass index. These patients also showed greater clinical activity, as evidenced by higher ASDAS-CRP, BASFI and BASMI scores (P < 0.05). In multivariate logistic regression, low TBS was associated with all disease parameters, except for BASMI: BASDAI (OR [95% CI] = 3.68 [1.48-9.19], P = 0.005), ASDAS-CRP (OR [95% CI] = 2.92 [1.20-7.10], P = 0.018), BASFI (OR [95% CI] = 1.04 [1.01-1.08], P = 0.018), BASMI (OR [95% CI] = 1.36 [0.99-1.87], P = 0.062). However, no association was observed between TBS and VFs.
UNASSIGNED: TBS was associated with active spondyloarthritis, suggesting increased bone fragility in these patients. However, TBS failed to demonstrate an association with VFs.
UNASSIGNED: Patients diagnosed with axial spondyloarthritis were included in this cross-sectional study. Dual-energy X-ray absorptiometry was used to measure BMD in the lumbar spine and TBS. Low TBS was defined as ≤1.31. The association between TBS and disease parameters including Ankylosing Spondylitis Disease Activity Score (ASDAS), BASDAI, BASFI and BASMI was studied using logistic regressions.
UNASSIGNED: Our study included 56 patients, with a mean age of 38.9 ± 13.5 years and a mean disease duration of 12.7 ± 7.7 years. Patients with low TBS were significantly older and had higher waist circumference and body mass index. These patients also showed greater clinical activity, as evidenced by higher ASDAS-CRP, BASFI and BASMI scores (P < 0.05). In multivariate logistic regression, low TBS was associated with all disease parameters, except for BASMI: BASDAI (OR [95% CI] = 3.68 [1.48-9.19], P = 0.005), ASDAS-CRP (OR [95% CI] = 2.92 [1.20-7.10], P = 0.018), BASFI (OR [95% CI] = 1.04 [1.01-1.08], P = 0.018), BASMI (OR [95% CI] = 1.36 [0.99-1.87], P = 0.062). However, no association was observed between TBS and VFs.
UNASSIGNED: TBS was associated with active spondyloarthritis, suggesting increased bone fragility in these patients. However, TBS failed to demonstrate an association with VFs.
摘要：
■我们旨在研究中轴型脊柱关节炎患者骨小梁评分（TBS）与疾病参数和椎体骨折（VFs）的相关性。
■被诊断为轴性脊柱关节炎的患者被纳入本横断面研究。双能X线骨密度仪用于测量腰椎和TBS的BMD。低TBS定义为≤1.31。TBS和疾病参数之间的关联，包括强直性脊柱炎疾病活动评分（ASDAS），BASDAI,使用逻辑回归研究BASFI和BASMI。
■我们的研究包括56名患者，平均年龄38.9±13.5岁，平均病程12.7±7.7岁。低TBS患者年龄明显较大，腰围和体重指数较高。这些患者还表现出更大的临床活动，更高的ASDAS-CRP证明，BASFI和BASMI评分(P<0.05)。在多变量逻辑回归中，低TBS与所有疾病参数相关，除了BASMI：BASDAI（OR[95%CI]=3.68[1.48-9.19]，P=0.005),ASDAS-CRP（OR[95%CI]=2.92[1.20-7.10]，P=0.018),BASFI（OR[95%CI]=1.04[1.01-1.08]，P=0.018),BASMI（OR[95%CI]=1.36[0.99-1.87]，P=0.062)。然而,未观察到TBS和VFs之间的关联.
■TBS与活动性脊柱关节炎有关，提示这些患者的骨脆性增加。然而,TBS未能证明与VF有关联。
■被诊断为轴性脊柱关节炎的患者被纳入本横断面研究。双能X线骨密度仪用于测量腰椎和TBS的BMD。低TBS定义为≤1.31。TBS和疾病参数之间的关联，包括强直性脊柱炎疾病活动评分（ASDAS），BASDAI,使用逻辑回归研究BASFI和BASMI。
■我们的研究包括56名患者，平均年龄38.9±13.5岁，平均病程12.7±7.7岁。低TBS患者年龄明显较大，腰围和体重指数较高。这些患者还表现出更大的临床活动，更高的ASDAS-CRP证明，BASFI和BASMI评分(P<0.05)。在多变量逻辑回归中，低TBS与所有疾病参数相关，除了BASMI：BASDAI（OR[95%CI]=3.68[1.48-9.19]，P=0.005),ASDAS-CRP（OR[95%CI]=2.92[1.20-7.10]，P=0.018),BASFI（OR[95%CI]=1.04[1.01-1.08]，P=0.018),BASMI（OR[95%CI]=1.36[0.99-1.87]，P=0.062)。然而,未观察到TBS和VFs之间的关联.
■TBS与活动性脊柱关节炎有关，提示这些患者的骨脆性增加。然而,TBS未能证明与VF有关联。
