PDF(Pubmed)
Abstract：
FAT1, a substantial transmembrane protein, plays a pivotal role in cellular adhesion and cell signaling. Numerous studies have documented frequent alterations in FAT1 across various cancer types, with its aberrant expression being linked to unfavorable survival rates and tumor progression. In the present investigation, we employed bioinformatic analyses, as well as in vitro and in vivo experiments to elucidate the functional significance of FAT1 in pan-cancer, with a primary focus on lung cancer. Our findings unveiled FAT1 overexpression in diverse cancer types, including lung cancer, concomitant with its association with an unfavorable prognosis. Furthermore, FAT1 is intricately involved in immune-related pathways and demonstrates a strong correlation with the expression of immune checkpoint genes. The suppression of FAT1 in lung cancer cells results in reduced cell proliferation, migration, and invasion. These collective findings suggest that FAT1 has potential utility both as a biomarker and as a therapeutic target for lung cancer.
摘要：
FAT1，一种重要的跨膜蛋白，在细胞粘附和细胞信号传导中起着关键作用。许多研究已经记录了FAT1在各种癌症类型中的频繁变化，其异常表达与不利的生存率和肿瘤进展有关。在目前的调查中,我们采用了生物信息学分析，以及体外和体内实验，以阐明FAT1在泛癌症中的功能意义，主要关注肺癌。我们的发现揭示了FAT1在不同癌症类型中的过度表达，包括肺癌,伴随着其与不良预后的关联。此外，FAT1复杂地参与免疫相关途径，并显示出与免疫检查点基因表达的强相关性。FAT1在肺癌细胞中的抑制导致细胞增殖减少,迁移,和入侵。这些集体发现表明FAT1具有作为生物标志物和作为肺癌治疗靶标的潜在效用。
