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Abstract：
Strongyloides stercoralis, commonly known as the human threadworm, is a skin-penetrating gastrointestinal parasitic nematode that infects hundreds of millions of people worldwide. Like other Strongyloides species, S. stercoralis is capable of cycling through a single free-living generation. Although S. stercoralis and the free-living nematode Caenorhabditis elegans are evolutionarily distant, the free-living adults of S. stercoralis are similar enough in size and morphology to C. elegans adults that techniques for generating transgenics and knockouts in C. elegans have been successfully adapted for use in S. stercoralis. High-quality genomic and transcriptomic data are also available for S. stercoralis. Thus, one can use a burgeoning array of functional genomic tools in S. stercoralis to probe questions about parasitic nematode development, physiology, and behavior. Knowledge gained from S. stercoralis will inform studies of other parasitic nematodes such as hookworms that are not yet amenable to genetic manipulation. This review describes the basic anatomy of S. stercoralis.
摘要：
胸骨圆线虫，通常被称为人类线虫，是一种皮肤穿透的胃肠道寄生线虫，感染了全球数亿人。像其他类圆线虫一样，S.stercoralis能够通过一个自由生活的一代骑自行车。尽管S.stercoralis和自由生活的线虫秀丽隐杆线虫在进化上是遥远的，胸骨S.的自由生活成虫在大小和形态上与秀丽隐杆线虫成虫足够相似,因此在秀丽隐杆线虫中产生转基因和基因敲除的技术已经成功地适用于胸骨S.高质量的基因组和转录组数据也可用于Stercoralis。因此，人们可以使用S.stercoralis中功能基因组工具的新兴阵列来探索有关寄生线虫发育的问题，生理学,和行为。从S.stercoralis获得的知识将为其他寄生线虫的研究提供信息，例如尚不适合进行遗传操作的钩虫。本文综述了胸骨S的基本解剖学。
