PDF(Pubmed)
Abstract：
UNASSIGNED: No clear-cut markers for predicting positive sperm retrieval (+SR) at microdissection testicular sperm extraction (mTESE) have been identified thus far. Our aim was to conduct a systematic review and meta-analysis to evaluate the ability of follicle-stimulating hormone (FSH), inhibin B (InhB), and anti-Müllerian hormone (AMH) to predict +SR in men with nonobstructive azoospermia (NOA) undergoing mTESE.
UNASSIGNED: We performed a search in the PubMed, EMBASE, Web of Science, and Scopus databases according to the Preferred Reporting Items for Systematic Review and Meta-analysis statement. Thirty-four publications were selected for inclusion in the analysis.
UNASSIGNED: Overall, the mean +SR rate was 45%. Pooled standardized mean difference (SMD) values revealed significant hormonal differences between the +SR and -SR groups, with lower FSH (SMD -0.30), higher InhB (SMD 0.54), and lower AMH (SMD -0.56) levels in the +SR group. Pooled odds ratios (Ors) revealed no significant prediction of +SR by either FSH (OR 1.03, 95% confidence interval [CI] 1.00-1.06) or InhB (OR 1.01, 95% CI 1.00-1.02), despite variations in baseline levels and study heterogeneity. Conversely, AMH had significant predictive value (OR 0.82, 95% CI 0.73-0.92), with lower baseline levels in the +SR group. InhB and FSH levels were higher in the +SR group, while InhB exhibited the opposite trend.
UNASSIGNED: Despite study heterogeneity, our meta-analysis findings support the ability of AMH to predict +SR for men with NOA undergoing mTESE.
UNASSIGNED: We conducted a review and analysis of results from previous studies. Our findings show that for men with an infertility condition called nonobstructive azoospermia, blood levels of anti-Müllerian hormone can predict successful extraction of sperm using a microsurgical technique. Levels of two other hormones did not predict successful sperm extraction.
UNASSIGNED: We performed a search in the PubMed, EMBASE, Web of Science, and Scopus databases according to the Preferred Reporting Items for Systematic Review and Meta-analysis statement. Thirty-four publications were selected for inclusion in the analysis.
UNASSIGNED: Overall, the mean +SR rate was 45%. Pooled standardized mean difference (SMD) values revealed significant hormonal differences between the +SR and -SR groups, with lower FSH (SMD -0.30), higher InhB (SMD 0.54), and lower AMH (SMD -0.56) levels in the +SR group. Pooled odds ratios (Ors) revealed no significant prediction of +SR by either FSH (OR 1.03, 95% confidence interval [CI] 1.00-1.06) or InhB (OR 1.01, 95% CI 1.00-1.02), despite variations in baseline levels and study heterogeneity. Conversely, AMH had significant predictive value (OR 0.82, 95% CI 0.73-0.92), with lower baseline levels in the +SR group. InhB and FSH levels were higher in the +SR group, while InhB exhibited the opposite trend.
UNASSIGNED: Despite study heterogeneity, our meta-analysis findings support the ability of AMH to predict +SR for men with NOA undergoing mTESE.
UNASSIGNED: We conducted a review and analysis of results from previous studies. Our findings show that for men with an infertility condition called nonobstructive azoospermia, blood levels of anti-Müllerian hormone can predict successful extraction of sperm using a microsurgical technique. Levels of two other hormones did not predict successful sperm extraction.
摘要：
■迄今为止，在显微切割睾丸精子提取（mTESE）时，尚未发现用于预测阳性精子回收（SR）的明确标记。我们的目的是进行系统评价和荟萃分析，以评估卵泡刺激素（FSH）的能力，抑制素B(InhB),和抗苗勒管激素（AMH）预测非梗阻性无精子症（NOA）患者接受mTESE的+SR。
■我们在PubMed中进行了搜索，EMBASE,WebofScience,和Scopus数据库，根据系统评价和荟萃分析声明的首选报告项目。选择34种出版物纳入分析。
■总的来说，平均+SR率为45%。汇总的标准化平均差（SMD）值揭示了+SR和-SR组之间的显着激素差异，具有较低的FSH（SMD-0.30），较高的InhB（SMD0.54），+SR组AMH(SMD-0.56)水平较低。汇总优势比（Ors）显示FSH（OR1.03，95％置信区间[CI]1.00-1.06）或InhB（OR1.01，95％CI1.00-1.02）对SR没有显着预测，尽管基线水平和研究异质性存在差异。相反，AMH具有显著的预测价值(OR0.82，95%CI0.73-0.92)，+SR组中基线水平较低。+SR组InhB和FSH水平较高，而InhB表现出相反的趋势。
■尽管研究存在异质性，我们的荟萃分析结果支持AMH对接受mTESE的NOA男性的+SR的预测能力。
■我们对以前的研究结果进行了回顾和分析。我们的发现表明，对于患有非阻塞性无精子症的不孕症的男性，抗苗勒管激素的血液水平可以预测使用显微外科技术成功提取精子。另外两种激素的水平并不能预测精子提取成功。
■我们在PubMed中进行了搜索，EMBASE,WebofScience,和Scopus数据库，根据系统评价和荟萃分析声明的首选报告项目。选择34种出版物纳入分析。
■总的来说，平均+SR率为45%。汇总的标准化平均差（SMD）值揭示了+SR和-SR组之间的显着激素差异，具有较低的FSH（SMD-0.30），较高的InhB（SMD0.54），+SR组AMH(SMD-0.56)水平较低。汇总优势比（Ors）显示FSH（OR1.03，95％置信区间[CI]1.00-1.06）或InhB（OR1.01，95％CI1.00-1.02）对SR没有显着预测，尽管基线水平和研究异质性存在差异。相反，AMH具有显著的预测价值(OR0.82，95%CI0.73-0.92)，+SR组中基线水平较低。+SR组InhB和FSH水平较高，而InhB表现出相反的趋势。
■尽管研究存在异质性，我们的荟萃分析结果支持AMH对接受mTESE的NOA男性的+SR的预测能力。
■我们对以前的研究结果进行了回顾和分析。我们的发现表明，对于患有非阻塞性无精子症的不孕症的男性，抗苗勒管激素的血液水平可以预测使用显微外科技术成功提取精子。另外两种激素的水平并不能预测精子提取成功。
