PDF(Pubmed)
Abstract：
Sterubin (7-O-Methyleriodicytol), a flavanone compound isolated from the leaves of Eriodicyton californicum and Eriodicyton angustifolium, has neuroprotective, anti-inflammatory, and antioxidant properties. Therefore, it is of interest to identify the potential targets for Alzheimer disease using network pharmacology. We report 25 overlapping targets among 100 potential targets of sterubin and 673 known targets of Alzheimer. APP, BACE-1, and AChE were among the ten hub targets enriched in biological processes and pathways relevant to Alzheimer\'s disease. Subsequent, molecular docking analysis shows that sterubin have optimal binding features with these hub gene targets for further consideration.
摘要：
胸苷（7-O-甲基草二醇），一种黄烷酮化合物，分离自大黄鱼和大黄鱼的叶子，具有神经保护作用,抗炎,和抗氧化性能。因此,使用网络药理学确定阿尔茨海默病的潜在靶标是有意义的.我们报告了100个潜在的类固醇目标和673个已知的阿尔茨海默氏症目标中的25个重叠目标。APP,BACE-1和AChE是富含与阿尔茨海默病相关的生物学过程和途径的十个中心靶标之一。随后,分子对接分析表明，胸骨与这些hub基因靶标具有最佳的结合特征，以供进一步考虑。
