PDF(Pubmed)
Abstract：
Takotsubo syndrome (TTS) is a rare disease mimicking acute coronary syndrome, often triggered by physical or emotional stress, and characterized by transient left ventricular dysfunction. Recurrences are described in about 5% of cases and may have different clinical and imaging patterns. In the present report, SARS-COV-2 infection, even in the absence of symptoms and overt emotional stress, seems correlated with recurrence of TTS, due to the absence of other recognized triggers. The hypothesis is that in predisposed patients, events like catecholamine-induced myocyte injury, direct viral damage, cytokine storm, immune-mediated damage, and procoagulant state, all possibly induced by the infection, may elicit endothelial dysfunction as substrate for TTS onset.
摘要：
Takotsubo综合征（TTS）是一种模仿急性冠状动脉综合征的罕见疾病，通常由身体或情绪压力引发，以短暂性左心室功能障碍为特征。在大约5％的病例中描述了复发，并且可能具有不同的临床和成像模式。在本报告中，SARS-COV-2感染,即使没有症状和明显的情绪压力，似乎与TTS的复发有关，由于缺少其他已识别的触发器。假设是在易感患者中，儿茶酚胺诱导的心肌细胞损伤等事件，直接病毒损害，细胞因子风暴，免疫介导的损伤，和促凝血状态，所有这些都可能是由感染引起的，可能引起内皮功能障碍作为TTS发作的底物。
