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Abstract：
UNASSIGNED: Smoking is a major risk factor for the group 3 PH. NT-proBNP is a biomarker for risk stratification in PH. This study aims to investigate the effects of smoking status and smoking index (SI) on group 3 PH and to evaluate the value of SI and SI combined with NT-proBNP in early diagnosis and prediction of disease severity.
UNASSIGNED: Four hundred patients with group 3 PH at the First Hospital of Shanxi Medical University between January 2020 and December 2021 were enrolled and divided into two groups: mild (30 mmHg ≤ pulmonary artery systolic pressure (PASP)≤50 mmHg) and non-mild (PASP >50 mmHg). The effect of smoking on group 3 PH was analyzed using univariate analysis, and logistic analysis was conducted to evaluate the risk of group 3 PH according to smoking status and SI. Spearman correlation coefficient was used to test the correlation between SI and the index of group 3 PH severity. The predictive value of SI was evaluated using a receiver operating characteristic (ROC) curve.
UNASSIGNED: Correlation and logistic analyses showed that SI was associated with PH severity. Smoking status (P=0.009) and SI (P=0.039) were independent risk factors for non-mild group 3 PH, and ROC showed that the predictive value of SI (AUC:0.596) for non-mild PH was better than that of the recognized pro-brain natriuretic peptide (NT-proBNP) (AUC:0.586). SI can be used as a single predictive marker. SI and NT-proBNP can be formulated as prediction models for screening non-mild clinical cases (AUC:0.628).
UNASSIGNED: SI is a potentially ideal non-invasive predictive marker for group 3 PH. SI and NT-proBNP could be used to develop a prediction model for screening non-mild PH cases. This can greatly improve the predictive specificity of the established PH marker, NT-proBNP.
UNASSIGNED: Four hundred patients with group 3 PH at the First Hospital of Shanxi Medical University between January 2020 and December 2021 were enrolled and divided into two groups: mild (30 mmHg ≤ pulmonary artery systolic pressure (PASP)≤50 mmHg) and non-mild (PASP >50 mmHg). The effect of smoking on group 3 PH was analyzed using univariate analysis, and logistic analysis was conducted to evaluate the risk of group 3 PH according to smoking status and SI. Spearman correlation coefficient was used to test the correlation between SI and the index of group 3 PH severity. The predictive value of SI was evaluated using a receiver operating characteristic (ROC) curve.
UNASSIGNED: Correlation and logistic analyses showed that SI was associated with PH severity. Smoking status (P=0.009) and SI (P=0.039) were independent risk factors for non-mild group 3 PH, and ROC showed that the predictive value of SI (AUC:0.596) for non-mild PH was better than that of the recognized pro-brain natriuretic peptide (NT-proBNP) (AUC:0.586). SI can be used as a single predictive marker. SI and NT-proBNP can be formulated as prediction models for screening non-mild clinical cases (AUC:0.628).
UNASSIGNED: SI is a potentially ideal non-invasive predictive marker for group 3 PH. SI and NT-proBNP could be used to develop a prediction model for screening non-mild PH cases. This can greatly improve the predictive specificity of the established PH marker, NT-proBNP.
摘要：
■吸烟是3组PH的主要危险因素。NT-proBNP是PH风险分层的生物标志物。本研究旨在探讨吸烟状况和吸烟指数(SI)对第3组PH的影响，并评价SI和SI联合NT-proBNP在早期诊断和预测疾病严重程度中的价值。
■选择2020年1月至2021年12月山西医科大学第一医院收治的3组PH患者400例，分为轻度(30mmHg≤肺动脉收缩压(PASP)≤50mmHg)和非轻度(PASP>50mmHg)两组。吸烟对第3组PH的影响采用单因素分析，根据吸烟状况和SI进行逻辑分析以评估第3组PH的风险。采用Spearman相关系数检验SI与第3组PH严重程度指标的相关性。使用受试者工作特征(ROC)曲线评价SI的预测值。
■相关性和逻辑分析表明SI与PH严重程度相关。吸烟状况(P=0.009)和SI(P=0.039)是非轻度3组PH的独立危险因素,和ROC显示，SI（AUC：0.596）对非轻度PH的预测价值优于公认的脑钠肽前体（NT-proBNP）（AUC：0.586）。SI可以用作单个预测标记。SI和NT-proBNP可作为筛选非轻度临床病例的预测模型(AUC:0.628)。
■SI是第3组PH的潜在理想非侵入性预测标志物。SI和NT-proBNP可用于建立筛查非轻度PH病例的预测模型。这可以大大提高已建立的PH标记的预测特异性，NT-proBNP.
■选择2020年1月至2021年12月山西医科大学第一医院收治的3组PH患者400例，分为轻度(30mmHg≤肺动脉收缩压(PASP)≤50mmHg)和非轻度(PASP>50mmHg)两组。吸烟对第3组PH的影响采用单因素分析，根据吸烟状况和SI进行逻辑分析以评估第3组PH的风险。采用Spearman相关系数检验SI与第3组PH严重程度指标的相关性。使用受试者工作特征(ROC)曲线评价SI的预测值。
■相关性和逻辑分析表明SI与PH严重程度相关。吸烟状况(P=0.009)和SI(P=0.039)是非轻度3组PH的独立危险因素,和ROC显示，SI（AUC：0.596）对非轻度PH的预测价值优于公认的脑钠肽前体（NT-proBNP）（AUC：0.586）。SI可以用作单个预测标记。SI和NT-proBNP可作为筛选非轻度临床病例的预测模型(AUC:0.628)。
■SI是第3组PH的潜在理想非侵入性预测标志物。SI和NT-proBNP可用于建立筛查非轻度PH病例的预测模型。这可以大大提高已建立的PH标记的预测特异性，NT-proBNP.
