PDF(Pubmed)
Abstract：
The need for organ transplants exceeds donor organ availability. In the quest to solve this shortage, the most remarkable area of advancement is organ production through the use of chimeric embryos, commonly known as blastocyst complementation. This technique involves the combination of different species to generate chimeras, where the extent of donor cell contribution to the desired tissue or organ can be regulated. However, ethical concerns arise with the use of brain tissue in such chimeras. Furthermore, the ratio of contributed cells to host animal cells in the chimeric system is low in the production of chimeras associated with cell apoptosis. This review discusses the latest innovations in blastocyst complementation and highlights the progress made in creating organs for transplant.
摘要：
器官移植的需求超过了供体器官的可用性。为了解决这种短缺，最显著的进步领域是通过使用嵌合胚胎产生器官，通常称为胚泡互补。这项技术涉及不同物种的组合以产生嵌合体，其中可以调节供体细胞对所需组织或器官的贡献程度。然而,在这种嵌合体中使用脑组织会引起伦理问题。此外，嵌合系统中贡献的细胞与宿主动物细胞的比率在与细胞凋亡相关的嵌合体的产生中是低的。这篇综述讨论了囊胚互补的最新创新，并强调了在创建移植器官方面取得的进展。
