PDF(Pubmed)
Abstract：
Background: While clinical research has indicated a potential link between Helicobacter pylori infection and the onset of glaucoma, the causality of this association remains uncertain due to the susceptibility of observational studies to confounding factors and reverse causation. Methods: A comprehensive two-sample bidirectional Mendelian randomization (MR) analysis was conducted to assess the causal connection between H. pylori infection and glaucoma. Glaucoma was categorized into primary open-angle glaucoma (POAG), normal tension glaucoma (NTG), and pseudo-exfoliation glaucoma (PEG). Various methods, including inverse variance weighted, MR-Egger regression, weighted median, and mode-based estimator, were employed for effect estimation and pleiotropy testing. To enhance result robustness, a sensitivity analysis was performed by excluding proxy single nucleotide polymorphisms. Results: Genetic predisposition for H. pylori infection has no causal effect on glaucoma: (OR 1.00; 95% CI 0.95-1.06, p = 0.980), (OR 0.97; 95% CI 0.86-1.09, p = 0.550), and (OR 0.99; 95% CI 0.90-1.08, p = 0.766) with POAG, NTG, and PEG, respectively. An inverse MR showed no causal effect of POAG, NTG, and PEG on H. pylori infection (OR 1.01; 95% CI 0.97-1.05, p = 0.693), (OR 1.00; 95% CI 0.98-1.03, p = 0.804), and (OR 0.99; 95% CI 0.96-1.01, p = 0.363), respectively. Heterogeneity (p > 0.05) and pleiotropy (p > 0.05) analysis confirmed the robustness of MR results. Conclusion: These results indicated that there was no genetic evidence for a causal link between H. pylori and glaucoma, suggesting that the eradication or prevention of H. pylori infection might not benefit glaucoma and vice versa.
摘要：
背景：虽然临床研究表明幽门螺杆菌感染与青光眼发病之间存在潜在的联系，由于观察性研究容易受到混杂因素和反向因果关系的影响,因此这种关联的因果关系仍不确定.方法：进行了全面的双样本双向孟德尔随机（MR）分析，以评估幽门螺杆菌感染与青光眼之间的因果关系。青光眼分为原发性开角型青光眼（POAG），正常眼压性青光眼（NTG），和假性剥脱性青光眼（PEG）。各种方法,包括逆方差加权，MR-Egger回归，加权中位数，和基于模式的估计器，用于效果估计和多效性测试。为了增强结果的鲁棒性，我们通过排除代理单核苷酸多态性进行了敏感性分析.结果：幽门螺杆菌感染的遗传易感性对青光眼没有因果关系：（OR1.00;95％CI0.95-1.06，p=0.980），（OR0.97；95%CI0.86-1.09，p=0.550），和(OR0.99；95%CI0.90-1.08，p=0.766)与POAG，NTG,和PEG，分别。反向MR显示POAG没有因果关系，NTG,和PEG对幽门螺杆菌感染的影响(OR1.01；95%CI0.97-1.05，p=0.693)，（OR1.00；95%CI0.98-1.03，p=0.804），和(OR0.99；95%CI0.96-1.01，p=0.363)，分别。异质性(p>0.05)和多效性(p>0.05)分析证实了MR结果的稳健性。结论：这些结果表明，没有遗传证据表明幽门螺杆菌与青光眼之间存在因果关系。提示根除或预防幽门螺杆菌感染可能对青光眼没有益处,反之亦然.
