PDF(Pubmed)
Abstract：
Acrokeratosis verruciformis of Hopf (AKVH) is a rare genetic skin condition associated with an ATP2A2 gene mutation, thus affecting keratinization. Classically, AKVH appears in childhood over acral sites as symmetrical, flat, verruca plana-like lesions with an autosomal dominant inheritance, while sporadic cases affect atypical sites in adulthood. As this entity can closely mimic other verrucous skin conditions, identifying characteristic histopathological changes is essential to make a diagnosis in the absence of genetic studies, especially in resource-poor countries. This is the first reported case of AKVH from North-East India clinically mimicking extensive verruca vulgaris in an adult with a possible sporadic occurrence. AKVH is usually difficult to treat and superficial ablation is the treatment of choice. However, this case highlights the role of cryotherapy with acitretin in the management of AKVH with a rapid response.
摘要：
Hopf的疣状去角化病（AKVH）是一种与ATP2A2基因突变相关的罕见遗传性皮肤病，从而影响角质化。经典的,AKVH在儿童期出现在肢端部位对称，扁平,具有常染色体显性遗传的扁平疣样病变，而散发性病例会影响成年期的非典型部位。由于该实体可以紧密模仿其他疣状皮肤状况，在缺乏基因研究的情况下，确定特征性组织病理学变化对于做出诊断至关重要，尤其是在资源匮乏的国家。这是印度东北部首例AKVH病例，临床上模仿成人广泛的寻常疣，可能有偶发性。AKVH通常难以治疗并且浅层消融是选择的治疗。然而,该病例强调了阿维A冷冻疗法在AKVH治疗中的作用,反应迅速.
