PDF(Pubmed)
Abstract：
Cervical intervertebral disc herniation is a common condition and most often presents as neck or upper limb pain causing varying levels of disability and dysfunction. Percutaneous injection of ozone into the intradiscal space is a novel and minimally invasive technique for managing this condition and can be an effective alternative to surgical management. A literature search was done using the keywords ozone disc nucleolysis of cervical intervertebral lesions, and five studies were selected based on the inclusion and exclusion criteria. Meta-analysis was performed to determine safety, effectiveness, and symptomatic relief (determined based on the visual analog scale (VAS)) with the publication bias being removed. Subjects treated with ozone therapy showed significant reduction (p < 0.0001) in VAS score as compared to baseline VAS score with a standardized mean difference of 2.78 (95% CI = 1.48 to 4.07; Z value = 4.20). Ozone nucleolysis is a minimally invasive, relatively safe, and optimally effective treatment option for reducing the pain related to cervical disc. Intradiscal ozone therapy can be considered an alternative treatment modality, and well-designed, randomized clinical trials are required to confirm the long-term superiority of ozone therapy against other treatment modalities available for cervical disc herniation.
摘要：
颈椎间盘突出是一种常见病，最常表现为颈部或上肢疼痛，导致不同程度的残疾和功能障碍。经皮将臭氧注入椎间盘间隙是一种新颖且微创的治疗方法，可以有效替代手术治疗。使用关键词臭氧椎间盘核溶解颈椎椎间病变进行了文献检索，根据纳入和排除标准选择了5项研究.进行Meta分析以确定安全性，有效性,和症状缓解（基于视觉模拟量表（VAS）确定），并消除发表偏倚。与基线VAS评分相比，接受臭氧治疗的受试者的VAS评分显着降低（p<0.0001），标准化平均差异为2.78（95％CI=1.48至4.07；Z值=4.20）。臭氧核溶解是一种微创的，相对安全,和最佳有效的治疗选择，以减少与颈椎间盘相关的疼痛。盘内臭氧治疗可以被认为是一种替代治疗方式。精心设计，需要进行随机临床试验,以证实臭氧疗法相对于其他可用于颈椎间盘突出症的治疗方式的长期优越性.
