PDF(Pubmed)
Abstract：
Postoperative atrial fibrillation (AF) is a known complication of postoperative morbidity and mortality in cardiac surgery. The purpose of this retrospective study was to look into the association between the incidence of new-onset AF in patients undergoing cardiac surgery and preoperative systemic inflammatory markers. Patients were divided into two groups (Group A: new-onset AF, Group B: no AF) depending on the occurrence of AF in the postoperative period, and a retrospective analysis was performed to look for the association between the incidence of new-onset AF and levels of systemic inflammatory markers. Five hundred patients were enrolled in the study, and the duration was three years. One-hundred and fifty out of 500 patients who underwent cardiac surgeries between 2020 and 2023 had higher levels of preoperative inflammatory markers. The systemic immune inflammation index (SII), neutrophil scores, platelet counts, and C-reactive protein (CRP) levels were examined. Compared to patients without AF (Group B), those who developed AF (Group A) had significantly higher mean levels of CRP (6.2 ± 1.8 mg/L), platelet count (320 ± 50 x109/L), neutrophil scores (4.6 ± 0.9), and SII (650 ± 120) (p<0.05 for all). Higher thresholds of these inflammatory markers were related to a notable increase in the prevalence of AF, with odds ratios showing significantly higher risks associated with raised marker levels. In summary, there was a significant correlation found between an increased risk of new-onset AF after surgery and elevated preoperative inflammatory markers, such as CRP levels, platelet counts, neutrophil scores, and SII. These findings could be used as prognostic markers to identify patients who are more likely to experience postoperative AF. Further prospective studies will be required to analyze their predictive value. Limitations of our study include the relatively small sample size, potential bias from single-institutional data, and the retrospective nature of the study design.
摘要：
术后心房颤动（AF）是心脏手术术后发病率和死亡率的已知并发症。这项回顾性研究的目的是探讨心脏手术患者新发房颤的发生率与术前全身炎症标志物之间的关系。患者分为两组（A组：新发房颤，B组：无AF）根据术后房颤的发生情况，我们进行了回顾性分析,以寻找新发房颤的发生率与全身炎症标志物水平之间的关联.该研究招募了500名患者，持续时间为三年。在2020年至2023年之间接受心脏手术的500名患者中，有150名术前炎症标志物水平较高。全身免疫炎症指数（SII），中性粒细胞评分,血小板计数,检测C反应蛋白(CRP)水平。与无房颤患者（B组）相比，发生房颤的患者（A组）的CRP平均水平明显较高（6.2±1.8mg/L），血小板计数（320±50x109/L），中性粒细胞评分（4.6±0.9），和SII(650±120)(均p<0.05)。这些炎症标志物的较高阈值与房颤患病率的显著增加有关。比值比显示与标志物水平升高相关的风险显着升高。总之,手术后新发房颤的风险增加和术前炎症标志物升高之间存在显著相关性。如CRP水平，血小板计数,中性粒细胞评分,和SII。这些发现可用作预后标志物，以识别更有可能发生术后房颤的患者。需要进一步的前瞻性研究来分析其预测价值。我们研究的局限性包括相对较小的样本量，来自单一机构数据的潜在偏见，和研究设计的回顾性性质。
